Abnormal gallbladder motility in irritable bowel syndrome: Evidence for target-organ defect

Patrick Sequeira Kamath, H. Y. Gaisano, S. F. Phillips, Laurence J Miller, J. W. Charboneau, M. L. Brown, A. R. Zinsmeister

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have described previously that the gallbladder responds abnormally to infusions of cholecystokinin octapeptide (CCK-8) in patients with irritable bowel syndrome (IBS). To confirm these results and to examine the possible mechanisms, patients with IBS and predominant symptoms of diarrhea or constipation were compared with matched controls. During infusions of CCK-8 at one of three doses, the response of the gallbladder was measured ultrasonographically. The levels of CCK-8 reached in the peripheral circulation and degradation of the peptide in vitro and in vivo were used to evaluate metabolism of cholecystokinin. We confirmed that the gallbladders of patients with IBS responded abnormally to CCK-8; however, the differences were not due to any prereceptor event. Instead, this abnormality in IBS must be explained by an atypical response at the level of the target tissues.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume260
Issue number6 23/6
StatePublished - 1991

Fingerprint

Sincalide
Irritable Bowel Syndrome
Gallbladder
Cholecystokinin
Constipation
Diarrhea
Peptides

Keywords

  • Cholecystokinin octapeptide
  • Smooth muscle

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Abnormal gallbladder motility in irritable bowel syndrome : Evidence for target-organ defect. / Kamath, Patrick Sequeira; Gaisano, H. Y.; Phillips, S. F.; Miller, Laurence J; Charboneau, J. W.; Brown, M. L.; Zinsmeister, A. R.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 260, No. 6 23/6, 1991.

Research output: Contribution to journalArticle

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