Abdominal aortic calcification, BMD, and bone microstructure: A population-based study

John T. Chow, Sundeep Khosla, L. Joseph Melton, Elizabeth J. Atkinson, Jon J. Camp, Ann E. Kearns

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To better define the relationship between vascular calcification and bone mass/structure, we assessed abdominal aortic calcification (AAC), BMD, and bone microstructure in an age-stratified, random sample of 693 Rochester, MN, residents. Participants underwent QCT of the spine and hip and high-resolution pQCT (HRpQCT) of the radius to define volumetric BMD (vBMD) and microstructural parameters. AAC was quantified with the Agatston scoring method. In men, AAC correlated with lower vertebral trabecular and femoral neck vBMD (p < 0.001), but not after age or multivariable (age, body mass index, smoking status) adjustment. Separation into <50 and ≥50 yr showed this pattern only in the older men. BV/TV and Tb.Th inversely correlated with AAC in all men (p < 0.001), and Tb.Th remained significantly correlated after age adjustment (p < 0.05). Tb.N positively correlated with AAC in younger men (p < 0.001) but negatively correlated in older men (p < 0.001). The opposite was true with Tb.Sp (p = 0.01 and p < 0.001, respectively). Lower Tb.N and higher Tb.Sp correlated with AAC in older men even after multivariable adjustment. Among all women and postmenopausal women, AAC correlated with lower vertebral and femoral neck vBMD (p < 0.001) but not after adjustment. Lower BV/TV and Tb.Th correlated with AAC (p = 0.03 and p = 0.04, respectively) in women, but not after adjustment. Our findings support an age-dependent association between AAC and vBMD. We also found that AAC correlates with specific bone microstructural parameters in older men, suggesting a possible common pathogenesis for vascular calcification and deterioration in bone structure. However, sex-specific differences exist.

Original languageEnglish (US)
Pages (from-to)1601-1612
Number of pages12
JournalJournal of Bone and Mineral Research
Volume23
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Social Adjustment
Bone and Bones
Population
Vascular Calcification
Femur Neck
Sex Characteristics
Hip
Spine
Body Mass Index
Research Design
Smoking

Keywords

  • Association
  • Bone composition
  • Bone QCT
  • Osteoporosis
  • Population studies

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Abdominal aortic calcification, BMD, and bone microstructure : A population-based study. / Chow, John T.; Khosla, Sundeep; Melton, L. Joseph; Atkinson, Elizabeth J.; Camp, Jon J.; Kearns, Ann E.

In: Journal of Bone and Mineral Research, Vol. 23, No. 10, 10.2008, p. 1601-1612.

Research output: Contribution to journalArticle

Chow, John T. ; Khosla, Sundeep ; Melton, L. Joseph ; Atkinson, Elizabeth J. ; Camp, Jon J. ; Kearns, Ann E. / Abdominal aortic calcification, BMD, and bone microstructure : A population-based study. In: Journal of Bone and Mineral Research. 2008 ; Vol. 23, No. 10. pp. 1601-1612.
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