AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis

Abhijeet Saha, Yogiraj Chopra, Jason D. Theis, Julie A. Vrana, Sanjeev Sethi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report a 12-year-old boy with nephrotic syndrome due to renal AA amyloidosis. The AA amyloidosis was associated with a 3-year history of systemic-onset juvenile idiopathic arthritis. The presence of serum amyloid A protein was confirmed by laser microdissection of Congo Red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry; this analysis excluded hereditary and familial amyloidosis. Aggressive management of the systemic-onset juvenile idiopathic arthritis resulted in improvement in clinical and laboratory parameters. The case represents an unusual cause of nephrotic syndrome in children. Early diagnosis of renal amyloidosis and management of systemic-onset juvenile idiopathic arthritis is paramount to preventing progression of kidney disease.

Original languageEnglish (US)
Pages (from-to)834-838
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume62
Issue number4
DOIs
StatePublished - Oct 1 2013

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Keywords

  • AA amyloid
  • mass spectrometry
  • proteomics
  • systemic-onset juvenile idiopathic arthritis

ASJC Scopus subject areas

  • Nephrology

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