Abstract
We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).
Original language | English (US) |
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Pages (from-to) | 2407-2412 |
Number of pages | 6 |
Journal | Nephrology Dialysis Transplantation |
Volume | 26 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- AA amyloid
- SAA variant
- hepatitis B
- mass spectrometry
- proteomics
ASJC Scopus subject areas
- Nephrology
- Transplantation