AA amyloidosis associated with hepatitis B

Abhijeet Saha, Jason D. Theis, Julie A. Vrana, Nand K. Dubey, Vineeta V. Batra, Sanjeev Sethi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).

Original languageEnglish (US)
Pages (from-to)2407-2412
Number of pages6
JournalNephrology Dialysis Transplantation
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • AA amyloid
  • SAA variant
  • hepatitis B
  • mass spectrometry
  • proteomics

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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