A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

Mario Hevesi, João F. Crispim, Carlo A. Paggi, Amel Dudakovic, Wouter Van Genechten, Timothy Hewett, Sanjeev Kakar, Aaron Krych, Andre J van Wijnen, Daniel B.F. Saris

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalTissue Engineering - Part C: Methods
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • animal models
  • anterior cruciate ligament
  • reconstruction

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

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    Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., Van Genechten, W., Hewett, T., Kakar, S., Krych, A., van Wijnen, A. J., & Saris, D. B. F. (2019). A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Tissue Engineering - Part C: Methods, 25(4), 191-196. https://doi.org/10.1089/ten.tec.2018.0357