A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

Mario Hevesi, João F. Crispim, Carlo A. Paggi, Amel Dudakovic, Wouter Van Genechten, Timothy Hewett, Sanjeev Kakar, Aaron Krych, Andre J van Wijnen, Daniel B.F. Saris

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalTissue Engineering - Part C: Methods
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Anterior Cruciate Ligament Reconstruction
Ligaments
Anterior Cruciate Ligament
Rabbits
Animal Care Committees
Veterinarians
Activities of Daily Living
Cartilage
Sports
Orthopedics
Animals
Animal Models
Research Personnel
Reconstruction (structural)
Wounds and Injuries
Research
Anterior Cruciate Ligament Injuries
Repair
Recovery

Keywords

  • animal models
  • anterior cruciate ligament
  • reconstruction

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Hevesi, M., Crispim, J. F., Paggi, C. A., Dudakovic, A., Van Genechten, W., Hewett, T., ... Saris, D. B. F. (2019). A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Tissue Engineering - Part C: Methods, 25(4), 191-196. https://doi.org/10.1089/ten.tec.2018.0357

A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. / Hevesi, Mario; Crispim, João F.; Paggi, Carlo A.; Dudakovic, Amel; Van Genechten, Wouter; Hewett, Timothy; Kakar, Sanjeev; Krych, Aaron; van Wijnen, Andre J; Saris, Daniel B.F.

In: Tissue Engineering - Part C: Methods, Vol. 25, No. 4, 01.04.2019, p. 191-196.

Research output: Contribution to journalArticle

Hevesi, M, Crispim, JF, Paggi, CA, Dudakovic, A, Van Genechten, W, Hewett, T, Kakar, S, Krych, A, van Wijnen, AJ & Saris, DBF 2019, 'A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model', Tissue Engineering - Part C: Methods, vol. 25, no. 4, pp. 191-196. https://doi.org/10.1089/ten.tec.2018.0357
Hevesi, Mario ; Crispim, João F. ; Paggi, Carlo A. ; Dudakovic, Amel ; Van Genechten, Wouter ; Hewett, Timothy ; Kakar, Sanjeev ; Krych, Aaron ; van Wijnen, Andre J ; Saris, Daniel B.F. / A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. In: Tissue Engineering - Part C: Methods. 2019 ; Vol. 25, No. 4. pp. 191-196.
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