TY - JOUR
T1 - A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model
AU - Hevesi, Mario
AU - Crispim, João F.
AU - Paggi, Carlo A.
AU - Dudakovic, Amel
AU - Van Genechten, Wouter
AU - Hewett, Timothy
AU - Kakar, Sanjeev
AU - Krych, Aaron J.
AU - Van Wijnen, Andre J.
AU - Saris, Daniel B.F.
N1 - Publisher Copyright:
© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
AB - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
KW - animal models
KW - anterior cruciate ligament
KW - reconstruction
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U2 - 10.1089/ten.tec.2018.0357
DO - 10.1089/ten.tec.2018.0357
M3 - Article
C2 - 30887885
AN - SCOPUS:85064535072
SN - 1937-3384
VL - 25
SP - 191
EP - 196
JO - Tissue Engineering - Part C: Methods
JF - Tissue Engineering - Part C: Methods
IS - 4
ER -