Abstract
Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-196 |
| Number of pages | 6 |
| Journal | Tissue Engineering - Part C: Methods |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2019 |
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Keywords
- animal models
- anterior cruciate ligament
- reconstruction
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
Cite this
A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model. / Hevesi, Mario; Crispim, João F.; Paggi, Carlo A.; Dudakovic, Amel; Van Genechten, Wouter; Hewett, Timothy; Kakar, Sanjeev; Krych, Aaron; van Wijnen, Andre J; Saris, Daniel B.F.
In: Tissue Engineering - Part C: Methods, Vol. 25, No. 4, 01.04.2019, p. 191-196.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model
AU - Hevesi, Mario
AU - Crispim, João F.
AU - Paggi, Carlo A.
AU - Dudakovic, Amel
AU - Van Genechten, Wouter
AU - Hewett, Timothy
AU - Kakar, Sanjeev
AU - Krych, Aaron
AU - van Wijnen, Andre J
AU - Saris, Daniel B.F.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
AB - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
KW - animal models
KW - anterior cruciate ligament
KW - reconstruction
UR - http://www.scopus.com/inward/record.url?scp=85064535072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064535072&partnerID=8YFLogxK
U2 - 10.1089/ten.tec.2018.0357
DO - 10.1089/ten.tec.2018.0357
M3 - Article
C2 - 30887885
AN - SCOPUS:85064535072
VL - 25
SP - 191
EP - 196
JO - Tissue Engineering - Part C: Methods
JF - Tissue Engineering - Part C: Methods
SN - 1937-3384
IS - 4
ER -