A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

Mario Hevesi; João F. Crispim; Carlo A. Paggi; Amel Dudakovic; Wouter Van Genechten; Timothy Hewett; Sanjeev Kakar; Aaron J. Krych; Andre J van Wijnen; Daniel B.F. Saris

doi:10.1089/ten.tec.2018.0357

A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

Mario Hevesi, João F. Crispim, Carlo A. Paggi, Amel Dudakovic, Wouter Van Genechten, Timothy Hewett, Sanjeev Kakar, Aaron J. Krych, Andre J van Wijnen, Daniel B.F. Saris

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	Tissue Engineering - Part C: Methods
Volume	25
Issue number	4
DOIs	https://doi.org/10.1089/ten.tec.2018.0357
State	Published - Apr 1 2019

Keywords

animal models
anterior cruciate ligament
reconstruction

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering

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10.1089/ten.tec.2018.0357

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title = "A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model",

abstract = "Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.",

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AU - Paggi, Carlo A.

AU - Dudakovic, Amel

AU - Van Genechten, Wouter

AU - Hewett, Timothy

AU - Kakar, Sanjeev

AU - Krych, Aaron J.

AU - van Wijnen, Andre J

AU - Saris, Daniel B.F.

PY - 2019/4/1

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N2 - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

AB - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.

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A Versatile Protocol for Studying Anterior Cruciate Ligament Reconstruction in a Rabbit Model

Abstract

Keywords

ASJC Scopus subject areas

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