A valid, accurate, office based non-radioactive test for gastric emptying of solids

J. S. Lee, M. Camilleri, A. R. Zinsmeister, D. D. Burton, L. J. Kost, P. D. Klein

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Background - Current breath tests for measurement of gastric emptying of solids are expensive, possibly inaccurate, and require cumbersome calculations. Aims - We wished to validate a simplified solid gastric emptying test using a [13C]Spirulina platensis breath test for accurate results relative to scintigraphy. Subjects - Thirty healthy volunteers. Methods - We measured gastric emptying of egg containing [13C]S platensis and 99mTc sulphur colloid by breath 13CO2 and scintigraphy over six hours. A generalised linear regression model was used to predict t(1/2) and t(LAG) by scintigraphy from breath 13CO2 data. The model was cross validated and normative data calculated for a prepacked [13C]meal. Results - Regression models using all breath data over six hours, for the first three hours, and for samples at 75, 90, and 180 minutes ('reduced model') predicted t(1/2) and t(LAG) values similar to scintigraphy (t(LAG) 43 (SD 12) min; t(1/2) 100 (20) min). Standard deviations of differences in t(1/2) and t(LAG) between scintigraphy and the 'reduced model' were both 10 minutes. Gastric t(1/2) for the prepacked [13G]meal was 91 (15) min (10-90% range: 74-118). Conclusion - The [13C]S platensis breath test and a simple formula using breath 13CO2 at baseline, 90, and 180 minutes measured gastric emptying t(1/2) for solids with results that were comparable with scintigraphy.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalGut
Volume46
Issue number6
DOIs
StatePublished - 2000

Keywords

  • Breath test
  • Gastric emptying
  • Stable isotope

ASJC Scopus subject areas

  • Gastroenterology

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    Lee, J. S., Camilleri, M., Zinsmeister, A. R., Burton, D. D., Kost, L. J., & Klein, P. D. (2000). A valid, accurate, office based non-radioactive test for gastric emptying of solids. Gut, 46(6), 768-773. https://doi.org/10.1136/gut.46.6.768