A valid, accurate, office based non-radioactive test for gastric emptying of solids

J. S. Lee, Michael Camilleri, A. R. Zinsmeister, D. D. Burton, L. J. Kost, P. D. Klein

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background - Current breath tests for measurement of gastric emptying of solids are expensive, possibly inaccurate, and require cumbersome calculations. Aims - We wished to validate a simplified solid gastric emptying test using a [ 13C]Spirulina platensis breath test for accurate results relative to scintigraphy. Subjects - Thirty healthy volunteers. Methods - We measured gastric emptying of egg containing [ 13C]S platensis and 99mTc sulphur colloid by breath 13CO 2 and scintigraphy over six hours. A generalised linear regression model was used to predict t(1/2) and t(LAG) by scintigraphy from breath 13CO 2 data. The model was cross validated and normative data calculated for a prepacked [ 13C]meal. Results - Regression models using all breath data over six hours, for the first three hours, and for samples at 75, 90, and 180 minutes ('reduced model') predicted t(1/2) and t(LAG) values similar to scintigraphy (t(LAG) 43 (SD 12) min; t(1/2) 100 (20) min). Standard deviations of differences in t(1/2) and t(LAG) between scintigraphy and the 'reduced model' were both 10 minutes. Gastric t(1/2) for the prepacked [ 13G]meal was 91 (15) min (10-90% range: 74-118). Conclusion - The [ 13C]S platensis breath test and a simple formula using breath 13CO 2 at baseline, 90, and 180 minutes measured gastric emptying t(1/2) for solids with results that were comparable with scintigraphy.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalGut
Volume46
Issue number6
DOIs
StatePublished - 2000

Fingerprint

Gastric Emptying
Radionuclide Imaging
Breath Tests
Meals
Linear Models
Spirulina
Colloids
Sulfur
Ovum
Stomach
Healthy Volunteers

Keywords

  • Breath test
  • Gastric emptying
  • Stable isotope

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lee, J. S., Camilleri, M., Zinsmeister, A. R., Burton, D. D., Kost, L. J., & Klein, P. D. (2000). A valid, accurate, office based non-radioactive test for gastric emptying of solids. Gut, 46(6), 768-773. https://doi.org/10.1136/gut.46.6.768

A valid, accurate, office based non-radioactive test for gastric emptying of solids. / Lee, J. S.; Camilleri, Michael; Zinsmeister, A. R.; Burton, D. D.; Kost, L. J.; Klein, P. D.

In: Gut, Vol. 46, No. 6, 2000, p. 768-773.

Research output: Contribution to journalArticle

Lee, JS, Camilleri, M, Zinsmeister, AR, Burton, DD, Kost, LJ & Klein, PD 2000, 'A valid, accurate, office based non-radioactive test for gastric emptying of solids', Gut, vol. 46, no. 6, pp. 768-773. https://doi.org/10.1136/gut.46.6.768
Lee, J. S. ; Camilleri, Michael ; Zinsmeister, A. R. ; Burton, D. D. ; Kost, L. J. ; Klein, P. D. / A valid, accurate, office based non-radioactive test for gastric emptying of solids. In: Gut. 2000 ; Vol. 46, No. 6. pp. 768-773.
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