A U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human g protein gene

Eric D. Wieben, Anne M. Vrabel, Eileen L. Holicky, Ivana Klisak, Robert S. Sparkes, David R. Stanford

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A complex locus on human chromosome 1 brings together sequences homologous to a G protein and two components of the RNA processing machinery of eukaryotic cells. Specifically, the seventh intron of the human Gi3α gene contains a fusion of a partial snRNP E protein pseudogene to a variant U6 snRNA gene. The novel U6 sequence contains nine point mutations and a one nucleotide deletion relative to the major U6 gene from humans. Unlike all other vertebrate U6 genes characterized to date, the variant U6 gene is efficiently transcribed by RNA polymerase III even in the absence of all natural flanking sequences. The union of elements from the signal transduction pathway and the RNA processing machinery suggests the possibility of functional interplay.

Original languageEnglish (US)
Pages (from-to)2869-2874
Number of pages6
JournalNucleic acids research
Volume19
Issue number11
DOIs
StatePublished - Jun 11 1991

ASJC Scopus subject areas

  • Genetics

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