A two-stage retention débridement protocol for acute periprosthetic joint infections

Chris S. Estes, Chris P. Beauchamp, Henry D. Clarke, Mark J. Spangehl

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Due to the historically poor infection control rates with débridement and component retention for acute periprosthetic infections we developed a new approach for treating acute periprosthetic total joint infections: initial débridement with prosthesis retention and placement of antibiotic-impregnated cement beads followed by a second débridement within 7 days, at which time the beads are removed and new modular parts inserted. Intravenous antibiotics were used for 6 weeks followed by oral antibiotics. Depending on the clinical situation, antibiotics are discontinued or in selected patients continued indefinitely. Questions/purposes: We determined the ability of this two-stage débridement to control infection. Methods: We retrospectively reviewed the charts of 20 patients who underwent this technique; 2 had postoperative and 18 had hematogenous infections. The primary outcome measure was the infection control. The minimum followup was 1 year (mean, 3.5 years; range, 1.2-7.5 years). Results: Two of the 20 patients had persistent infection. There were no failures in the acute postoperative group (0 of 2) and two of 18 in the acute hematogenous group. Of the 18 patients without evidence of persistent infection, 10 were no longer on antibiotics at the most recent followup and eight were treated with long-term antibiotics due to compromised host status. Conclusions: The control of infection in 18 of 20 patients using this technique compares favorably with historical success rates, which range from 24% to 100%. Further research is required to analyze the individual contribution of débridement technique, the use of serial débridements, local depot antibiotics, and combination antibiotic therapy on short-term infection control rates and the long-term persistent control of periprosthetic infection. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of level of evidence.

Original languageEnglish (US)
Pages (from-to)2029-2038
Number of pages10
JournalClinical Orthopaedics and Related Research
Volume468
Issue number8
DOIs
StatePublished - Aug 2010

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Infection Control
Joints
Anti-Bacterial Agents
Infection
Prosthesis Retention
Outcome Assessment (Health Care)
Guidelines
Therapeutics
Research

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

A two-stage retention débridement protocol for acute periprosthetic joint infections. / Estes, Chris S.; Beauchamp, Chris P.; Clarke, Henry D.; Spangehl, Mark J.

In: Clinical Orthopaedics and Related Research, Vol. 468, No. 8, 08.2010, p. 2029-2038.

Research output: Contribution to journalArticle

Estes, Chris S. ; Beauchamp, Chris P. ; Clarke, Henry D. ; Spangehl, Mark J. / A two-stage retention débridement protocol for acute periprosthetic joint infections. In: Clinical Orthopaedics and Related Research. 2010 ; Vol. 468, No. 8. pp. 2029-2038.
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abstract = "Background: Due to the historically poor infection control rates with d{\'e}bridement and component retention for acute periprosthetic infections we developed a new approach for treating acute periprosthetic total joint infections: initial d{\'e}bridement with prosthesis retention and placement of antibiotic-impregnated cement beads followed by a second d{\'e}bridement within 7 days, at which time the beads are removed and new modular parts inserted. Intravenous antibiotics were used for 6 weeks followed by oral antibiotics. Depending on the clinical situation, antibiotics are discontinued or in selected patients continued indefinitely. Questions/purposes: We determined the ability of this two-stage d{\'e}bridement to control infection. Methods: We retrospectively reviewed the charts of 20 patients who underwent this technique; 2 had postoperative and 18 had hematogenous infections. The primary outcome measure was the infection control. The minimum followup was 1 year (mean, 3.5 years; range, 1.2-7.5 years). Results: Two of the 20 patients had persistent infection. There were no failures in the acute postoperative group (0 of 2) and two of 18 in the acute hematogenous group. Of the 18 patients without evidence of persistent infection, 10 were no longer on antibiotics at the most recent followup and eight were treated with long-term antibiotics due to compromised host status. Conclusions: The control of infection in 18 of 20 patients using this technique compares favorably with historical success rates, which range from 24{\%} to 100{\%}. Further research is required to analyze the individual contribution of d{\'e}bridement technique, the use of serial d{\'e}bridements, local depot antibiotics, and combination antibiotic therapy on short-term infection control rates and the long-term persistent control of periprosthetic infection. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of level of evidence.",
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