A tripeptidyl ensemble perspective of interactive control of growth hormone secretion

Johannes D. Veldhuis

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.

Original languageEnglish (US)
Pages (from-to)86-101
Number of pages16
JournalHormone Research
Volume60
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 22 2003

Keywords

  • Gender
  • Ghrelin
  • Growth hormone
  • Growth hormone-releasing hormone
  • Growth hormone-releasing peptide
  • Insulin-like growth factor I
  • Oestradiol
  • Oestrogen
  • Sex-steroid hormones
  • Somatostatin
  • Threefold peptide control pathway
  • Women

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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