A trial of proficiency of nerve conduction: Greater standardization still needed

Peter J Dyck, James W. Albers, James Wolfe, Charles F. Bolton, Nancy Walsh, Christopher Jon Klein, Andrew J. Zafft, James W. Russell, Karen Thomas, Jenny L. Davies, Rickey E. Carter, L. Joseph Melton, William J Litchy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introduction: The aim of this study was to test the proficiency (accuracy among evaluators) of measured attributes of nerve conduction (NC). Methods: Expert clinical neurophysiologists, without instruction or consensus development, from 4 different medical centers, independently assessed 8 attributes of NC in 24 patients with diabetes mellitus (DM) on consecutive days. Results: No significant intraobserver differences between days 1 and 2 were found, but significant interobserver differences were seen. Use of standard reference values did not correct for these observed differences. Conclusions: Interobserver variability was attributed to differences in performance of NC. It was of sufficient magnitude that it is of concern for the conduct of therapeutic trials. To deal with interrater variability in therapeutic trials, the same electromyographers should perform all NC assessments of individual patients or, preferably, NC procedures should be more standardized. A further trial is needed to test whether such standardization would eliminate interobserver variability.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalMuscle and Nerve
Volume48
Issue number3
DOIs
StatePublished - Sep 2013

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Neural Conduction
Observer Variation
Consensus
Diabetes Mellitus
Reference Values
Therapeutics

Keywords

  • Clinical trial
  • Diabetic sensorimotor polyneuropathy
  • Nerve conduction
  • Proficiency
  • Standard reference value

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

A trial of proficiency of nerve conduction : Greater standardization still needed. / Dyck, Peter J; Albers, James W.; Wolfe, James; Bolton, Charles F.; Walsh, Nancy; Klein, Christopher Jon; Zafft, Andrew J.; Russell, James W.; Thomas, Karen; Davies, Jenny L.; Carter, Rickey E.; Melton, L. Joseph; Litchy, William J.

In: Muscle and Nerve, Vol. 48, No. 3, 09.2013, p. 369-374.

Research output: Contribution to journalArticle

Dyck, PJ, Albers, JW, Wolfe, J, Bolton, CF, Walsh, N, Klein, CJ, Zafft, AJ, Russell, JW, Thomas, K, Davies, JL, Carter, RE, Melton, LJ & Litchy, WJ 2013, 'A trial of proficiency of nerve conduction: Greater standardization still needed', Muscle and Nerve, vol. 48, no. 3, pp. 369-374. https://doi.org/10.1002/mus.23765
Dyck, Peter J ; Albers, James W. ; Wolfe, James ; Bolton, Charles F. ; Walsh, Nancy ; Klein, Christopher Jon ; Zafft, Andrew J. ; Russell, James W. ; Thomas, Karen ; Davies, Jenny L. ; Carter, Rickey E. ; Melton, L. Joseph ; Litchy, William J. / A trial of proficiency of nerve conduction : Greater standardization still needed. In: Muscle and Nerve. 2013 ; Vol. 48, No. 3. pp. 369-374.
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