A total radiation dose of 70 Gy is required after macroscopically incomplete resection of squamous cell carcinoma of the head and neck

Dirk Rades, Stefan Janssen, Amira Bajrovic, Primoz Strojan, Steven E. Schild

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Aim: To contribute to the definition of the optimal total radiation dose and to determine the role of concurrent chemotherapy after macroscopically incomplete resection of squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Twenty-six patients treated with postoperative radio(chemo)therapy following macroscopically incomplete resection were evaluated. Total radiation dose (70 Gy vs. 59.4-66 Gy), concurrent chemotherapy (yes vs. no) plus six factors were investigated for locoregional control (LRC) and overall survival (OS). Results: On analyses of LRC, 70 Gy was significantly superior to 59.4-66.0 Gy. Twoyear LCR rates were 94% and 25%, respectively (p<0.001). Concurrent chemotherapy significantly improved 2-year LRC (90% vs. 0%, p<0.001). Both 70 Gy (92% vs. 11%, p<0.001) and concurrent chemotherapy (80% vs.0%, p<0.001) also resulted in better OS. Conclusion: A total radiation dose of 70 Gy was significantly superior to lower doses regarding both LCR and OS. Concurrent chemotherapy is also very important to achieve optimal outcomes.

Original languageEnglish (US)
Pages (from-to)2989-2992
Number of pages4
JournalAnticancer Research
Volume36
Issue number6
StatePublished - Jun 1 2016

Keywords

  • Concurrent chemotherapy
  • Locoregional control
  • Macroscopically incomplete resection
  • SCCHN
  • Survival
  • Total radiation dose

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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