Abstract
Objectives/Hypothesis: Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy. Study Design: Bench and animal research. Methods: A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1 year, the construct was first evaluated in vivo with high-speed imaging and acoustic–aerodynamic measures. It was then explanted and evaluated histologically. Results: The canine study at 1 year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long-term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti-infective agents were needed after the standard perioperative medications were completed. Conclusion: This study provided a successful first step toward developing a patient-specific composite construct for patients undergoing partial laryngectomies. Level of Evidence: NA Laryngoscope, 132:S1–S11, 2022.
Original language | English (US) |
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Pages (from-to) | S1-S11 |
Journal | Laryngoscope |
Volume | 132 |
Issue number | S9 |
DOIs | |
State | Published - Jun 2022 |
Keywords
- Tissue engineering
- airway reconstruction
- epithelialization
- partial laryngectomy
ASJC Scopus subject areas
- Otorhinolaryngology