TY - JOUR
T1 - A systems biology approach to the effect of aging, immunosenescence and vaccine response
AU - Poland, Gregory A.
AU - Ovsyannikova, Inna G.
AU - Kennedy, Richard B.
AU - Lambert, Nathaniel D.
AU - Kirkland, James L.
N1 - Funding Information:
The authors wish to thank Caroline L. Vitse for her editorial assistance. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award/contract numbers U01AI089859 , R37AI048793 (which recently received a MERIT Award) R01AI033144 and HHSN266200400065C (AI40065) . The content is solely the responsibility of the authors, and does not necessarily represent the official views of the National Institutes of Health.
PY - 2014/8
Y1 - 2014/8
N2 - Aging can lead to immunosenescence, which dramatically impairs the hosts' ability to develop protective immune responses to vaccine antigens. Reasons for this are not well understood. This topic's importance is reflected in the increases in morbidity and mortality due to infectious diseases among elderly persons, a population growing in size globally, and the significantly lower adaptive immune responses generated to vaccines in this population. Here, we endeavor to summarize the existing data on the genetic and immunologic correlates of immunosenescence with respect to vaccine response. We cover how the application of systems biology can advance our understanding of vaccine immunosenescence, with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly.
AB - Aging can lead to immunosenescence, which dramatically impairs the hosts' ability to develop protective immune responses to vaccine antigens. Reasons for this are not well understood. This topic's importance is reflected in the increases in morbidity and mortality due to infectious diseases among elderly persons, a population growing in size globally, and the significantly lower adaptive immune responses generated to vaccines in this population. Here, we endeavor to summarize the existing data on the genetic and immunologic correlates of immunosenescence with respect to vaccine response. We cover how the application of systems biology can advance our understanding of vaccine immunosenescence, with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly.
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U2 - 10.1016/j.coi.2014.04.005
DO - 10.1016/j.coi.2014.04.005
M3 - Review article
C2 - 24820347
AN - SCOPUS:84900012738
SN - 0952-7915
VL - 29
SP - 62
EP - 68
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -