A systems biology approach to the effect of aging, immunosenescence and vaccine response

Gregory A. Poland, Inna G. Ovsyannikova, Richard B. Kennedy, Nathaniel D. Lambert, James L. Kirkland

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Aging can lead to immunosenescence, which dramatically impairs the hosts' ability to develop protective immune responses to vaccine antigens. Reasons for this are not well understood. This topic's importance is reflected in the increases in morbidity and mortality due to infectious diseases among elderly persons, a population growing in size globally, and the significantly lower adaptive immune responses generated to vaccines in this population. Here, we endeavor to summarize the existing data on the genetic and immunologic correlates of immunosenescence with respect to vaccine response. We cover how the application of systems biology can advance our understanding of vaccine immunosenescence, with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalCurrent Opinion in Immunology
Volume29
Issue number1
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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