A systematic review of the use of Botulinum toxin type A with subpectoral breast implants

Sebastian Winocour, Mohammad H Murad, Mahsa Bidgoli-Moghaddam, Steven R. Jacobson, Uldis Bite, Michel Saint-Cyr, Nho V. Tran, Valerie Lemaine

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To determine the efficacy of Botulinum toxin A (BTX-A) injections for pain relief following placement of subpectoral tissue expanders and breast implants. Methods MEDLINE and EMBASE were searched from their inception to December 2012 to identify studies reporting the efficacy of perioperative BTX-A injections following breast surgery with subpectoral prostheses. Study designs included controlled and uncontrolled studies. Results Seven studies met the inclusion criteria (2 prospective controlled cohort, 3 retrospective cohort and 2 case series). Five studies assessed the efficacy of BTX-A and three measured pain improvement as a primary outcome. The studies enrolled 427 women: 91.8% received intraoperative BTX-A injection at the time of tissue expander breast reconstruction and 4.7% following augmentation mammaplasty. Only 3.5% of women received BTX-A injections in the postoperative setting. Overall, all the studies demonstrated improvement in pain and favorable side effect profile without any major adverse effects. However, the quality of this evidence was low. Conclusion The results of this systematic review suggest that BTX-A may alleviate postoperative pain associated with the placement of subpectoral tissue expanders and implants. The available data on outcome assessment of this practice are inconsistent and lack methodological rigor. With paucity of high-level evidence to support this practice in implant-based breast surgery, further studies are needed.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalJournal of Plastic, Reconstructive and Aesthetic Surgery
Volume67
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Breast Implants
Type A Botulinum Toxins
Tissue Expansion Devices
Injections
Mammaplasty
Pain
Postoperative Pain
MEDLINE
Prostheses and Implants
Breast
Outcome Assessment (Health Care)

Keywords

  • Botulinum toxin A
  • Breast implants
  • Breast reconstruction
  • Postoperative pain
  • Tissue expanders

ASJC Scopus subject areas

  • Surgery

Cite this

A systematic review of the use of Botulinum toxin type A with subpectoral breast implants. / Winocour, Sebastian; Murad, Mohammad H; Bidgoli-Moghaddam, Mahsa; Jacobson, Steven R.; Bite, Uldis; Saint-Cyr, Michel; Tran, Nho V.; Lemaine, Valerie.

In: Journal of Plastic, Reconstructive and Aesthetic Surgery, Vol. 67, No. 1, 01.2014, p. 34-41.

Research output: Contribution to journalArticle

Winocour, S, Murad, MH, Bidgoli-Moghaddam, M, Jacobson, SR, Bite, U, Saint-Cyr, M, Tran, NV & Lemaine, V 2014, 'A systematic review of the use of Botulinum toxin type A with subpectoral breast implants', Journal of Plastic, Reconstructive and Aesthetic Surgery, vol. 67, no. 1, pp. 34-41. https://doi.org/10.1016/j.bjps.2013.09.012
Winocour, Sebastian ; Murad, Mohammad H ; Bidgoli-Moghaddam, Mahsa ; Jacobson, Steven R. ; Bite, Uldis ; Saint-Cyr, Michel ; Tran, Nho V. ; Lemaine, Valerie. / A systematic review of the use of Botulinum toxin type A with subpectoral breast implants. In: Journal of Plastic, Reconstructive and Aesthetic Surgery. 2014 ; Vol. 67, No. 1. pp. 34-41.
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