TY - JOUR
T1 - A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease
AU - Thakkar, Samarthkumar
AU - Arora, Shilpkumar
AU - Kumar, Ashish
AU - Jaswaney, Rahul
AU - Faisaluddin, Mohammed
AU - Ammad Ud Din, Mohammad
AU - Shariff, Mariam
AU - Barssoum, Kirolos
AU - Patel, Harsh P.
AU - Nirav, Arora
AU - Jani, Chinmay
AU - Patel, Kripa
AU - Savani, Sejal
AU - DeSimone, Christopher
AU - Mulpuru, Siva
AU - Deshmukh, Abhishek
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020
Y1 - 2020
N2 - The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.
AB - The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.
KW - COVID-19
KW - CV outcomes
KW - acute coronary syndrome
KW - myocarditis
KW - stroke
KW - thrombosis
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U2 - 10.1177/1179546820977196
DO - 10.1177/1179546820977196
M3 - Review article
AN - SCOPUS:85097097785
SN - 1179-5468
VL - 14
JO - Clinical Medicine Insights: Cardiology
JF - Clinical Medicine Insights: Cardiology
ER -