A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease

Samarthkumar Thakkar, Shilpkumar Arora, Ashish Kumar, Rahul Jaswaney, Mohammed Faisaluddin, Mohammad Ammad Ud Din, Mariam Shariff, Kirolos Barssoum, Harsh P. Patel, Arora Nirav, Chinmay Jani, Kripa Patel, Sejal Savani, Christopher DeSimone, Siva Mulpuru, Abhishek Deshmukh

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.

Original languageEnglish (US)
JournalClinical Medicine Insights: Cardiology
StatePublished - 2020


  • COVID-19
  • CV outcomes
  • acute coronary syndrome
  • myocarditis
  • stroke
  • thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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