A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography

Pengfei Song; Xiaojun Bi; Daniel C. Mellema; Armando Manduca; Matthew W Urban; James F Greenleaf; Shigao D Chen

doi:10.1109/ULTSYM.2015.0153

A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography

Pengfei Song, Xiaojun Bi, Daniel C. Mellema, Armando Manduca, Matthew W Urban, James F Greenleaf, Shigao D Chen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Recent advancement in cardiac shear wave elastography (SWE) using pulse-inversion harmonic imaging showed substantial improvement of shear wave motion detection and demonstrated feasibility of transthoracic measurement of human myocardial stiffness. This study aimed at systematically investigating the feasible echocardiographic views for cardiac SWE and the impact of myocardial anisotropy when measuring myocardial stiffness from different scan views transthoracically. Ten healthy volunteers were recruited and scanned three times on three different days. A cardiac SWE sequence with pulse-inversion harmonic imaging and time-aligned sequential tracking was used to measure quantitative myocardial stiffness in late diastole. Seven combinations of echocardiography views and left ventricular (LV) segments were found to be feasible for transthoracic cardiac SWE: basal interventricular septum (IVS) under parasternal short-axis and long-axis views; mid IVS under parasternal short-axis and long-axis views; anterior LV free wall under parasternal short-axis and long-axis views; and posterior LV free wall under parasternal short-axis view. On the same LV segment, the mean diastolic shear wave speed (SWS) measurements from the short-axis view were statistically different from the long-axis view: 1.82 vs. 1.29 m/s for basal IVS; 1.81 vs. 1.45 m/s for mid IVS; and 1.96 vs. 1.77 m/s for anterior LV free wall, indicating that myocardial anisotropy plays a significant role in cardiac SWE measurements. These results establish the preliminary normal range of myocardial SWS under different scan views and provide important guidance for future clinical studies using cardiac SWE.

Original language	English (US)
Title of host publication	2015 IEEE International Ultrasonics Symposium, IUS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479981823
DOIs	https://doi.org/10.1109/ULTSYM.2015.0153
State	Published - Nov 13 2015
Event	IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: Oct 21 2015 → Oct 24 2015

Other

Other	IEEE International Ultrasonics Symposium, IUS 2015
Country/Territory	Taiwan, Province of China
City	Taipei
Period	10/21/15 → 10/24/15

Keywords

anisotropy
echocardiographic views
myocardial stiffness
shear wave elastography

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2015.0153

Cite this

Song, P., Bi, X., Mellema, D. C., Manduca, A., Urban, M. W., Greenleaf, J. F., & Chen, S. D. (2015). A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329157] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2015.0153

A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography. / Song, Pengfei; Bi, Xiaojun; Mellema, Daniel C. et al.

2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7329157.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Song, P, Bi, X, Mellema, DC, Manduca, A , Urban, MW , Greenleaf, JF & Chen, SD 2015, A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329157, Institute of Electrical and Electronics Engineers Inc., IEEE International Ultrasonics Symposium, IUS 2015, Taipei, Taiwan, Province of China, 10/21/15. https://doi.org/10.1109/ULTSYM.2015.0153

Song P, Bi X, Mellema DC, Manduca A , Urban MW , Greenleaf JF et al. A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography. In 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7329157 doi: 10.1109/ULTSYM.2015.0153

@inproceedings{bd59f84ef8fe46c8a40876d17504475a,

title = "A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography",

abstract = "Recent advancement in cardiac shear wave elastography (SWE) using pulse-inversion harmonic imaging showed substantial improvement of shear wave motion detection and demonstrated feasibility of transthoracic measurement of human myocardial stiffness. This study aimed at systematically investigating the feasible echocardiographic views for cardiac SWE and the impact of myocardial anisotropy when measuring myocardial stiffness from different scan views transthoracically. Ten healthy volunteers were recruited and scanned three times on three different days. A cardiac SWE sequence with pulse-inversion harmonic imaging and time-aligned sequential tracking was used to measure quantitative myocardial stiffness in late diastole. Seven combinations of echocardiography views and left ventricular (LV) segments were found to be feasible for transthoracic cardiac SWE: basal interventricular septum (IVS) under parasternal short-axis and long-axis views; mid IVS under parasternal short-axis and long-axis views; anterior LV free wall under parasternal short-axis and long-axis views; and posterior LV free wall under parasternal short-axis view. On the same LV segment, the mean diastolic shear wave speed (SWS) measurements from the short-axis view were statistically different from the long-axis view: 1.82 vs. 1.29 m/s for basal IVS; 1.81 vs. 1.45 m/s for mid IVS; and 1.96 vs. 1.77 m/s for anterior LV free wall, indicating that myocardial anisotropy plays a significant role in cardiac SWE measurements. These results establish the preliminary normal range of myocardial SWS under different scan views and provide important guidance for future clinical studies using cardiac SWE.",

keywords = "anisotropy, echocardiographic views, myocardial stiffness, shear wave elastography",

author = "Pengfei Song and Xiaojun Bi and Mellema, {Daniel C.} and Armando Manduca and Urban, {Matthew W} and Greenleaf, {James F} and Chen, {Shigao D}",

year = "2015",

month = nov,

day = "13",

doi = "10.1109/ULTSYM.2015.0153",

language = "English (US)",

isbn = "9781479981823",

booktitle = "2015 IEEE International Ultrasonics Symposium, IUS 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "IEEE International Ultrasonics Symposium, IUS 2015 ; Conference date: 21-10-2015 Through 24-10-2015",

}

TY - GEN

T1 - A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography

AU - Song, Pengfei

AU - Bi, Xiaojun

AU - Mellema, Daniel C.

AU - Manduca, Armando

AU - Urban, Matthew W

AU - Greenleaf, James F

AU - Chen, Shigao D

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Recent advancement in cardiac shear wave elastography (SWE) using pulse-inversion harmonic imaging showed substantial improvement of shear wave motion detection and demonstrated feasibility of transthoracic measurement of human myocardial stiffness. This study aimed at systematically investigating the feasible echocardiographic views for cardiac SWE and the impact of myocardial anisotropy when measuring myocardial stiffness from different scan views transthoracically. Ten healthy volunteers were recruited and scanned three times on three different days. A cardiac SWE sequence with pulse-inversion harmonic imaging and time-aligned sequential tracking was used to measure quantitative myocardial stiffness in late diastole. Seven combinations of echocardiography views and left ventricular (LV) segments were found to be feasible for transthoracic cardiac SWE: basal interventricular septum (IVS) under parasternal short-axis and long-axis views; mid IVS under parasternal short-axis and long-axis views; anterior LV free wall under parasternal short-axis and long-axis views; and posterior LV free wall under parasternal short-axis view. On the same LV segment, the mean diastolic shear wave speed (SWS) measurements from the short-axis view were statistically different from the long-axis view: 1.82 vs. 1.29 m/s for basal IVS; 1.81 vs. 1.45 m/s for mid IVS; and 1.96 vs. 1.77 m/s for anterior LV free wall, indicating that myocardial anisotropy plays a significant role in cardiac SWE measurements. These results establish the preliminary normal range of myocardial SWS under different scan views and provide important guidance for future clinical studies using cardiac SWE.

AB - Recent advancement in cardiac shear wave elastography (SWE) using pulse-inversion harmonic imaging showed substantial improvement of shear wave motion detection and demonstrated feasibility of transthoracic measurement of human myocardial stiffness. This study aimed at systematically investigating the feasible echocardiographic views for cardiac SWE and the impact of myocardial anisotropy when measuring myocardial stiffness from different scan views transthoracically. Ten healthy volunteers were recruited and scanned three times on three different days. A cardiac SWE sequence with pulse-inversion harmonic imaging and time-aligned sequential tracking was used to measure quantitative myocardial stiffness in late diastole. Seven combinations of echocardiography views and left ventricular (LV) segments were found to be feasible for transthoracic cardiac SWE: basal interventricular septum (IVS) under parasternal short-axis and long-axis views; mid IVS under parasternal short-axis and long-axis views; anterior LV free wall under parasternal short-axis and long-axis views; and posterior LV free wall under parasternal short-axis view. On the same LV segment, the mean diastolic shear wave speed (SWS) measurements from the short-axis view were statistically different from the long-axis view: 1.82 vs. 1.29 m/s for basal IVS; 1.81 vs. 1.45 m/s for mid IVS; and 1.96 vs. 1.77 m/s for anterior LV free wall, indicating that myocardial anisotropy plays a significant role in cardiac SWE measurements. These results establish the preliminary normal range of myocardial SWS under different scan views and provide important guidance for future clinical studies using cardiac SWE.

KW - anisotropy

KW - echocardiographic views

KW - myocardial stiffness

KW - shear wave elastography

UR - http://www.scopus.com/inward/record.url?scp=84962016589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962016589&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2015.0153

DO - 10.1109/ULTSYM.2015.0153

M3 - Conference contribution

AN - SCOPUS:84962016589

SN - 9781479981823

BT - 2015 IEEE International Ultrasonics Symposium, IUS 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - IEEE International Ultrasonics Symposium, IUS 2015

Y2 - 21 October 2015 through 24 October 2015

ER -

A systematic investigation of feasible acoustic windows and the impact of myocardial anisotropy for in vivo human cardiac shear wave elastography

Abstract

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this