A system for the analysis of whole-bone strength from helical CT images

Jon J. Camp, Ronald A. Karwoski, Mahlon C. Stacy, Elizabeth J. Atkinson, Sundeep Khosla, L. Joseph Melton, B. Lawrence Riggs, Richard A. Robb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Citations (Scopus)

Abstract

Osteoporosis affects an estimated 44 million Americans. This condition results from bone loss, but the measured change in bone mass does not fully account for the marked decrease in whole-bone structural integrity seen in osteoporosis. In order to study structural changes in bone mineral distribution due to normal ageing and osteoporosis, we have developed a method for progressive analysis of whole-bone mechanical integrity from helical CT images. The system provides rapid semi-automated alignment of femur and vertebrae volume images into standard anatomic reference planes, and calculates bone mineral density in any selected 3D sections of bone. Mineral density measures are obtained u.s,ing both full-width-half-max contours and threshold-derived masks, and are obtained for cortical bone and trabecular bone separately. Biomechanical properties of the bone cross-section are also assessed, including the 2-D bending moment of the cortical bone region and the integrated flexural rigidity of the cortical region or whole-bone region in arbitrary planes. This method facilitates progressive refinement of the analysis protocol by separating the labor-intensive alignment and landmark selection process from the analysis process. As the analysis protocol evolves to include new measures, previously analyzed images can be automatically reanalyzed, using the image regions originally specified. Initial results show inverse correlation of indices of biomechanical bone strength with age, greater loss of bone strength in the lumbar spine than in the femoral neck, and more trabecular than cortical bone loss at both sites.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.A. Amini, A. Mandura
Pages74-88
Number of pages15
Volume5369
DOIs
StatePublished - 2004
EventMedical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 15 2004Feb 17 2004

Other

OtherMedical Imaging 2004: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/15/042/17/04

Fingerprint

bones
Bone
osteoporosis
Minerals
minerals
integrity
alignment
vertebrae
femur
bending moments
landmarks
spine
labor
Structural integrity
Bending moments
rigidity
Rigidity
Masks
masks
Aging of materials

Keywords

  • Bending rigidity
  • Biomechanics
  • Bone
  • Bone mineral density
  • Compressive rigidity
  • Osteoporosis
  • QCT

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., ... Robb, R. A. (2004). A system for the analysis of whole-bone strength from helical CT images. In A. A. Amini, & A. Mandura (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5369, pp. 74-88) https://doi.org/10.1117/12.535745

A system for the analysis of whole-bone strength from helical CT images. / Camp, Jon J.; Karwoski, Ronald A.; Stacy, Mahlon C.; Atkinson, Elizabeth J.; Khosla, Sundeep; Melton, L. Joseph; Riggs, B. Lawrence; Robb, Richard A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / A.A. Amini; A. Mandura. Vol. 5369 2004. p. 74-88.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Camp, JJ, Karwoski, RA, Stacy, MC, Atkinson, EJ, Khosla, S, Melton, LJ, Riggs, BL & Robb, RA 2004, A system for the analysis of whole-bone strength from helical CT images. in AA Amini & A Mandura (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5369, pp. 74-88, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/15/04. https://doi.org/10.1117/12.535745
Camp JJ, Karwoski RA, Stacy MC, Atkinson EJ, Khosla S, Melton LJ et al. A system for the analysis of whole-bone strength from helical CT images. In Amini AA, Mandura A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5369. 2004. p. 74-88 https://doi.org/10.1117/12.535745
Camp, Jon J. ; Karwoski, Ronald A. ; Stacy, Mahlon C. ; Atkinson, Elizabeth J. ; Khosla, Sundeep ; Melton, L. Joseph ; Riggs, B. Lawrence ; Robb, Richard A. / A system for the analysis of whole-bone strength from helical CT images. Proceedings of SPIE - The International Society for Optical Engineering. editor / A.A. Amini ; A. Mandura. Vol. 5369 2004. pp. 74-88
@inproceedings{f0e64c502ad244c8992bc8dd3927f7ed,
title = "A system for the analysis of whole-bone strength from helical CT images",
abstract = "Osteoporosis affects an estimated 44 million Americans. This condition results from bone loss, but the measured change in bone mass does not fully account for the marked decrease in whole-bone structural integrity seen in osteoporosis. In order to study structural changes in bone mineral distribution due to normal ageing and osteoporosis, we have developed a method for progressive analysis of whole-bone mechanical integrity from helical CT images. The system provides rapid semi-automated alignment of femur and vertebrae volume images into standard anatomic reference planes, and calculates bone mineral density in any selected 3D sections of bone. Mineral density measures are obtained u.s,ing both full-width-half-max contours and threshold-derived masks, and are obtained for cortical bone and trabecular bone separately. Biomechanical properties of the bone cross-section are also assessed, including the 2-D bending moment of the cortical bone region and the integrated flexural rigidity of the cortical region or whole-bone region in arbitrary planes. This method facilitates progressive refinement of the analysis protocol by separating the labor-intensive alignment and landmark selection process from the analysis process. As the analysis protocol evolves to include new measures, previously analyzed images can be automatically reanalyzed, using the image regions originally specified. Initial results show inverse correlation of indices of biomechanical bone strength with age, greater loss of bone strength in the lumbar spine than in the femoral neck, and more trabecular than cortical bone loss at both sites.",
keywords = "Bending rigidity, Biomechanics, Bone, Bone mineral density, Compressive rigidity, Osteoporosis, QCT",
author = "Camp, {Jon J.} and Karwoski, {Ronald A.} and Stacy, {Mahlon C.} and Atkinson, {Elizabeth J.} and Sundeep Khosla and Melton, {L. Joseph} and Riggs, {B. Lawrence} and Robb, {Richard A.}",
year = "2004",
doi = "10.1117/12.535745",
language = "English (US)",
volume = "5369",
pages = "74--88",
editor = "A.A. Amini and A. Mandura",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - A system for the analysis of whole-bone strength from helical CT images

AU - Camp, Jon J.

AU - Karwoski, Ronald A.

AU - Stacy, Mahlon C.

AU - Atkinson, Elizabeth J.

AU - Khosla, Sundeep

AU - Melton, L. Joseph

AU - Riggs, B. Lawrence

AU - Robb, Richard A.

PY - 2004

Y1 - 2004

N2 - Osteoporosis affects an estimated 44 million Americans. This condition results from bone loss, but the measured change in bone mass does not fully account for the marked decrease in whole-bone structural integrity seen in osteoporosis. In order to study structural changes in bone mineral distribution due to normal ageing and osteoporosis, we have developed a method for progressive analysis of whole-bone mechanical integrity from helical CT images. The system provides rapid semi-automated alignment of femur and vertebrae volume images into standard anatomic reference planes, and calculates bone mineral density in any selected 3D sections of bone. Mineral density measures are obtained u.s,ing both full-width-half-max contours and threshold-derived masks, and are obtained for cortical bone and trabecular bone separately. Biomechanical properties of the bone cross-section are also assessed, including the 2-D bending moment of the cortical bone region and the integrated flexural rigidity of the cortical region or whole-bone region in arbitrary planes. This method facilitates progressive refinement of the analysis protocol by separating the labor-intensive alignment and landmark selection process from the analysis process. As the analysis protocol evolves to include new measures, previously analyzed images can be automatically reanalyzed, using the image regions originally specified. Initial results show inverse correlation of indices of biomechanical bone strength with age, greater loss of bone strength in the lumbar spine than in the femoral neck, and more trabecular than cortical bone loss at both sites.

AB - Osteoporosis affects an estimated 44 million Americans. This condition results from bone loss, but the measured change in bone mass does not fully account for the marked decrease in whole-bone structural integrity seen in osteoporosis. In order to study structural changes in bone mineral distribution due to normal ageing and osteoporosis, we have developed a method for progressive analysis of whole-bone mechanical integrity from helical CT images. The system provides rapid semi-automated alignment of femur and vertebrae volume images into standard anatomic reference planes, and calculates bone mineral density in any selected 3D sections of bone. Mineral density measures are obtained u.s,ing both full-width-half-max contours and threshold-derived masks, and are obtained for cortical bone and trabecular bone separately. Biomechanical properties of the bone cross-section are also assessed, including the 2-D bending moment of the cortical bone region and the integrated flexural rigidity of the cortical region or whole-bone region in arbitrary planes. This method facilitates progressive refinement of the analysis protocol by separating the labor-intensive alignment and landmark selection process from the analysis process. As the analysis protocol evolves to include new measures, previously analyzed images can be automatically reanalyzed, using the image regions originally specified. Initial results show inverse correlation of indices of biomechanical bone strength with age, greater loss of bone strength in the lumbar spine than in the femoral neck, and more trabecular than cortical bone loss at both sites.

KW - Bending rigidity

KW - Biomechanics

KW - Bone

KW - Bone mineral density

KW - Compressive rigidity

KW - Osteoporosis

KW - QCT

UR - http://www.scopus.com/inward/record.url?scp=3042597711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042597711&partnerID=8YFLogxK

U2 - 10.1117/12.535745

DO - 10.1117/12.535745

M3 - Conference contribution

AN - SCOPUS:3042597711

VL - 5369

SP - 74

EP - 88

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Amini, A.A.

A2 - Mandura, A.

ER -