A syrian golden hamster model recapitulating ebola hemorrhagic fever

Hideki Ebihara, Marko Zivcec, Donald Gardner, Darryl Falzarano, Rachel Lacasse, Rebecca Rosenke, Dan Long, Elaine Haddock, Elizabeth Fischer, Yoshihiro Kawaoka, Heinz Feldmann

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or vaccine is currently available. While the nonhuman primate (NHP) model is used for final evaluation of experimental vaccines and therapeutic efficacy, rodent models have been widely used in ebolavirus research because of their convenience. However, the validity of rodent models has been questioned given their low predictive value for efficacy testing of vaccines and therapeutics, a result of the inconsistent manifestation of coagulopathy seen in EHF. Here, we describe a lethal Syrian hamster model of EHF using mouse-adapted Ebola virus. Infected hamsters displayed most clinical hallmarks of EHF, including severe coagulopathy and uncontrolled host immune responses. Thus, the hamster seems to be superior to the existing rodent models, offering a better tool for understanding the critical processes in pathogenesis and providing a new model for evaluating prophylactic and postexposure interventions prior to testing in NHPs.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalJournal of Infectious Diseases
Volume207
Issue number2
DOIs
StatePublished - 2013

Keywords

  • Ebola hemorrhagic fever
  • animal model
  • coagulopathy
  • ebolavirus
  • pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'A syrian golden hamster model recapitulating ebola hemorrhagic fever'. Together they form a unique fingerprint.

  • Cite this

    Ebihara, H., Zivcec, M., Gardner, D., Falzarano, D., Lacasse, R., Rosenke, R., Long, D., Haddock, E., Fischer, E., Kawaoka, Y., & Feldmann, H. (2013). A syrian golden hamster model recapitulating ebola hemorrhagic fever. Journal of Infectious Diseases, 207(2), 306-318. https://doi.org/10.1093/infdis/jis626