A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative

Ian Clark, Sejal M Shah, Roger Moreira, Rondell Graham, Tsung-Teh Wu, Michael Torbenson, Vishal Chandan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a common malignancy both in the United States of America and worldwide. Despite the refinement of imaging techniques in at-risk populations, a needle biopsy diagnosis remains an important diagnostic tool for HCC in many cases. Various immunohistochemical markers have been developed to facilitate this diagnosis, such as HepPar-1, glypican-3 and, most recently, arginase-1. Amongst them, arginase-1 has been shown to have superior sensitivity and specificity than the others. Performance of arginase-1 has been reported to be excellent for diagnosis of well-differentiated HCCs, with some tail-off in sensitivity for poorly differentiated tumors. Our experience has suggested that a subset of well-differentiated HCCs can be negative for arginase-1. We examined 68 consecutive confirmed cases of well-differentiated HCC diagnosed on needle biopsy, and found 7 (10%) to be completely negative for arginase-1. This finding is of fundamental clinical importance in view of previous studies that have shown arginase-1 to be always positive in well-differentiated HCC.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalHuman Pathology
Volume69
DOIs
StatePublished - Nov 1 2017

Fingerprint

Arginase
Hepatocellular Carcinoma
Needle Biopsy
Glypicans
Neoplasms
Sensitivity and Specificity

Keywords

  • Arginase-1
  • Hepatocellular carcinoma
  • Liver
  • Well differentiated

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative. / Clark, Ian; Shah, Sejal M; Moreira, Roger; Graham, Rondell; Wu, Tsung-Teh; Torbenson, Michael; Chandan, Vishal.

In: Human Pathology, Vol. 69, 01.11.2017, p. 90-95.

Research output: Contribution to journalArticle

Clark, Ian ; Shah, Sejal M ; Moreira, Roger ; Graham, Rondell ; Wu, Tsung-Teh ; Torbenson, Michael ; Chandan, Vishal. / A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative. In: Human Pathology. 2017 ; Vol. 69. pp. 90-95.
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AU - Torbenson, Michael

AU - Chandan, Vishal

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