A study of microRNAs in silico and in vivo: Diagnostic and therapeutic applications in cancer

Scott A. Waldman, Andre Terzic

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.

Original languageEnglish (US)
Pages (from-to)2157-2164
Number of pages8
JournalFEBS Journal
Volume276
Issue number8
DOIs
StatePublished - Apr 2009

Fingerprint

MicroRNAs
Computer Simulation
Tumors
Neoplasms
Therapeutics
Dermatoglyphics
Tumor Biomarkers
Carcinogenesis
Tissue

Keywords

  • Biomarkers
  • Cancer
  • Diagnosis
  • Individualized therapy
  • MicroRNA
  • Prediction
  • Prognosis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

A study of microRNAs in silico and in vivo : Diagnostic and therapeutic applications in cancer. / Waldman, Scott A.; Terzic, Andre.

In: FEBS Journal, Vol. 276, No. 8, 04.2009, p. 2157-2164.

Research output: Contribution to journalArticle

@article{442ae4a30ff140eb8c4cb653f6123a32,
title = "A study of microRNAs in silico and in vivo: Diagnostic and therapeutic applications in cancer",
abstract = "There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.",
keywords = "Biomarkers, Cancer, Diagnosis, Individualized therapy, MicroRNA, Prediction, Prognosis",
author = "Waldman, {Scott A.} and Andre Terzic",
year = "2009",
month = "4",
doi = "10.1111/j.1742-4658.2009.06934.x",
language = "English (US)",
volume = "276",
pages = "2157--2164",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - A study of microRNAs in silico and in vivo

T2 - Diagnostic and therapeutic applications in cancer

AU - Waldman, Scott A.

AU - Terzic, Andre

PY - 2009/4

Y1 - 2009/4

N2 - There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.

AB - There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.

KW - Biomarkers

KW - Cancer

KW - Diagnosis

KW - Individualized therapy

KW - MicroRNA

KW - Prediction

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=63049115244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63049115244&partnerID=8YFLogxK

U2 - 10.1111/j.1742-4658.2009.06934.x

DO - 10.1111/j.1742-4658.2009.06934.x

M3 - Article

C2 - 19250312

AN - SCOPUS:63049115244

VL - 276

SP - 2157

EP - 2164

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 8

ER -