A study of candidate genotypes associated with dyspepsia in a U.S. community

Christopher E. Camilleri, Paula J. Carlson, Michael Camilleri, Emma J. Castillo, G. Richard Locke, Debra M. Geno, Debra A. Stephens, Alan R. Zinsmeister, Raul Urrutia

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.

Original languageEnglish (US)
Pages (from-to)581-592
Number of pages12
JournalAmerican Journal of Gastroenterology
Volume101
Issue number3
DOIs
StatePublished - Mar 2006

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Dyspepsia
Genotype
Meals
Adrenergic Agents
Alleles
Cholecystokinin A Receptor
Genes
Serotonin Plasma Membrane Transport Proteins
Genetic Predisposition to Disease
Protein C
GTP-Binding Proteins
Physical Examination
Serotonin
History
DNA

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Camilleri, C. E., Carlson, P. J., Camilleri, M., Castillo, E. J., Locke, G. R., Geno, D. M., ... Urrutia, R. (2006). A study of candidate genotypes associated with dyspepsia in a U.S. community. American Journal of Gastroenterology, 101(3), 581-592. https://doi.org/10.1111/j.1572-0241.2006.00481.x

A study of candidate genotypes associated with dyspepsia in a U.S. community. / Camilleri, Christopher E.; Carlson, Paula J.; Camilleri, Michael; Castillo, Emma J.; Locke, G. Richard; Geno, Debra M.; Stephens, Debra A.; Zinsmeister, Alan R.; Urrutia, Raul.

In: American Journal of Gastroenterology, Vol. 101, No. 3, 03.2006, p. 581-592.

Research output: Contribution to journalArticle

Camilleri, CE, Carlson, PJ, Camilleri, M, Castillo, EJ, Locke, GR, Geno, DM, Stephens, DA, Zinsmeister, AR & Urrutia, R 2006, 'A study of candidate genotypes associated with dyspepsia in a U.S. community', American Journal of Gastroenterology, vol. 101, no. 3, pp. 581-592. https://doi.org/10.1111/j.1572-0241.2006.00481.x
Camilleri, Christopher E. ; Carlson, Paula J. ; Camilleri, Michael ; Castillo, Emma J. ; Locke, G. Richard ; Geno, Debra M. ; Stephens, Debra A. ; Zinsmeister, Alan R. ; Urrutia, Raul. / A study of candidate genotypes associated with dyspepsia in a U.S. community. In: American Journal of Gastroenterology. 2006 ; Vol. 101, No. 3. pp. 581-592.
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abstract = "BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.",
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AU - Locke, G. Richard

AU - Geno, Debra M.

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N2 - BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.

AB - BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.

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