TY - JOUR
T1 - A study of candidate genotypes associated with dyspepsia in a U.S. community
AU - Camilleri, Christopher E.
AU - Carlson, Paula J.
AU - Camilleri, Michael
AU - Castillo, Emma J.
AU - Locke, G. Richard
AU - Geno, Debra M.
AU - Stephens, Debra A.
AU - Zinsmeister, Alan R.
AU - Urrutia, Raul
PY - 2006/3
Y1 - 2006/3
N2 - BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.
AB - BACKGROUND: The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNβ3. AIM: To explore the association of candidate genotypes altering adrenergic, serotonergic, CCKergic, and G protein functions, and dyspepsia in a sample from a U.S. community. METHODS: Dyspeptics and healthy controls were identified among community respondents who had been randomly selected to complete validated questionnaires. Other diseases were excluded by face-to-face history and physical examination. Polymorphisms of candidate genes for α2A, α2C, 5-HT1A, 5-HT 2A, 5-HT2C, CCK-1 receptors and CCK promoter, GNβ3 protein, and SERT-promoter (SERT-P) were studied. The association between polymorphisms and meal-related or meal-unrelated dyspepsia, high somatic symptom scores, and somatization were evaluated using Fisher's exact test. RESULTS: DNA was available from 41 dyspeptics and 47 healthy controls from Olmsted County. Community dyspepsia unrelated to meals was associated with both homozygous GNβ3 protein 825T and C alleles. There were no significant associations with meal-related dyspepsia. Using Rome II subgroups, the same genotype was associated with dysmotility-like and other dyspepsia. Higher somatization scores were not significantly associated with any of the candidate genes when considered as single factors. CONCLUSION: Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNβ3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.
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U2 - 10.1111/j.1572-0241.2006.00481.x
DO - 10.1111/j.1572-0241.2006.00481.x
M3 - Article
C2 - 16464220
AN - SCOPUS:33644774923
SN - 0002-9270
VL - 101
SP - 581
EP - 592
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -