Abstract
A calcium-sensitive, lipid-activated protein kinase is present in ovarian granulosa cells and may modulate granulosa cell function through an effect on granulosa cells prostaglandin F2 alpha biosynthesis. Phorbol-ester activation of this protein kinase elicits a dose- and time-dependent augmentation in the synthesis of PGF2 alpha by swine granulosa cells which can be inhibited by inhibitors of prostaglandin and protein synthesis. Our studies support a linkage between protein kinase C activation and prostaglandin F2 alpha synthesis by these cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1117-1121 |
| Number of pages | 5 |
| Journal | Advances in prostaglandin, thromboxane, and leukotriene research |
| Volume | 17 B |
| State | Published - 1987 |
ASJC Scopus subject areas
- General Medicine