@article{cb748dfb90b64caa9debdae5f62b3507,
title = "A stepwise approach for effective management of chronic pain in autosomal-dominant polycystic kidney disease",
abstract = "Chronic pain, defined as pain existing for >4-6 weeks, affects >60% of patients with autosomal-dominant polycystic disease (ADPKD). It can have various causes, indirectly or directly related to the increase in kidney and liver volume in these patients. Chronic pain in ADPKD patients is often severe, impacting physical activity and social relationships, and frequently difficult to manage. This review provides an overview of pathophysiological mechanisms that can lead to pain and discusses the sensory innervation of the kidneys and the upper abdominal organs, including the liver. In addition, the results of a systematic literature search of ADPKD-specific treatment options are presented. Based on pathophysiological knowledge and evidence derived from the literature an argumentative stepwise approach for effective management of chronic pain in ADPKD is proposed.",
keywords = "ADPKD, Management, Pain, Polycystic kidney disease, Polycystic liver disease",
author = "{on behalf of the DIPAK Consortium} and Casteleijn, {Niek F.} and Visser, {Folkert W.} and Drenth, {Joost P.H.} and Gevers, {Tom J.G.} and Groen, {Gerbrand J.} and Hogan, {Marie C.} and Gansevoort, {Ron T.} and {De Fijter}, {J. W.} and Peters, {D. J.M.} and J. Wetzels and R. Zietse",
note = "Funding Information: The DIPAK Consortium is an inter-university collaboration in The Netherlands that is established to study Autosomal Dominant Polycystic Kidney Disease and to develop rational treatment strategies for this disease. The DIPAK Consortium is sponsored by the Dutch Kidney Foundation (grant CP10.12). Principal investigators are (in alphabetical order): J.P.H. Drenth (Department of Gastroenterology and Hepatology, Radboud University Medical Center Nijmegen), J.W. de Fijter (Department Nephrology, Leiden University Medical Center), R.T. Gansevoort (Department of Nephrology, University Medical Center Groningen), D.J.M. Peters (Department of Human Genetics, Leiden University Medical Center), J. Wetzels (Department of Nephrology, Radboud University Medical Center Nijmegen), R. Zietse (Department of Internal Medicine, Erasmus Medical Center Rotterdam). Publisher Copyright: {\textcopyright} The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.",
year = "2014",
doi = "10.1093/ndt/gfu073",
language = "English (US)",
volume = "29",
pages = "iv142--iv153",
journal = "Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress",
issn = "0931-0509",
publisher = "Oxford University Press",
}