A stepwise approach for effective management of chronic pain in autosomal-dominant polycystic kidney disease.

Niek F. Casteleijn, Folkert W. Visser, Joost P H Drenth, Tom J G Gevers, Gerbrand J. Groen, Marie C Hogan, Ron T. Gansevoort, Consortium DIPAK Consortium

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chronic pain, defined as pain existing for >4-6 weeks, affects >60% of patients with autosomal-dominant polycystic disease (ADPKD). It can have various causes, indirectly or directly related to the increase in kidney and liver volume in these patients. Chronic pain in ADPKD patients is often severe, impacting physical activity and social relationships, and frequently difficult to manage. This review provides an overview of pathophysiological mechanisms that can lead to pain and discusses the sensory innervation of the kidneys and the upper abdominal organs, including the liver. In addition, the results of a systematic literature search of ADPKD-specific treatment options are presented. Based on pathophysiological knowledge and evidence derived from the literature an argumentative stepwise approach for effective management of chronic pain in ADPKD is proposed.

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Autosomal Dominant Polycystic Kidney
Chronic Pain
Kidney
Pain
Liver
Exercise
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A stepwise approach for effective management of chronic pain in autosomal-dominant polycystic kidney disease. / Casteleijn, Niek F.; Visser, Folkert W.; Drenth, Joost P H; Gevers, Tom J G; Groen, Gerbrand J.; Hogan, Marie C; Gansevoort, Ron T.; DIPAK Consortium, Consortium.

In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 29 Suppl 4, 2014.

Research output: Contribution to journalArticle

Casteleijn, Niek F. ; Visser, Folkert W. ; Drenth, Joost P H ; Gevers, Tom J G ; Groen, Gerbrand J. ; Hogan, Marie C ; Gansevoort, Ron T. ; DIPAK Consortium, Consortium. / A stepwise approach for effective management of chronic pain in autosomal-dominant polycystic kidney disease. In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 ; Vol. 29 Suppl 4.
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