A stepwise approach for effective management of chronic pain in autosomal-dominant polycystic kidney disease

on behalf of the DIPAK Consortium

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Chronic pain, defined as pain existing for >4-6 weeks, affects >60% of patients with autosomal-dominant polycystic disease (ADPKD). It can have various causes, indirectly or directly related to the increase in kidney and liver volume in these patients. Chronic pain in ADPKD patients is often severe, impacting physical activity and social relationships, and frequently difficult to manage. This review provides an overview of pathophysiological mechanisms that can lead to pain and discusses the sensory innervation of the kidneys and the upper abdominal organs, including the liver. In addition, the results of a systematic literature search of ADPKD-specific treatment options are presented. Based on pathophysiological knowledge and evidence derived from the literature an argumentative stepwise approach for effective management of chronic pain in ADPKD is proposed.

Original languageEnglish (US)
Pages (from-to)iv142-iv153
JournalNephrology Dialysis Transplantation
Volume29
DOIs
StatePublished - 2014

Keywords

  • ADPKD
  • Management
  • Pain
  • Polycystic kidney disease
  • Polycystic liver disease

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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