TY - JOUR
T1 - A Step-By-Step Surgical Protocol for the Treatment of Perianal Fistula with Adipose-Derived Mesenchymal Stem Cells
AU - Georgiev-Hristov, Tihomir
AU - Guadalajara, H.
AU - Herreros, M. D.
AU - Lightner, A. L.
AU - Dozois, E. J.
AU - García-Arranz, M.
AU - García-Olmo, D.
N1 - Publisher Copyright:
© 2018, The Society for Surgery of the Alimentary Tract.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Anal fistula is a challenging condition both for surgeons and patients. Recurrent fistula, Crohn’s disease, or autoimmune disorders add further complexity to this situation. Numerous clinical trials have now demonstrated that cell-based therapy appears to be a good complement to fistulous surgery. As in any new treatment, especially that involving living cells, appropriate application is paramount to achieve optimal outcomes. As stem cell-based treatments are gaining a strong foothold in fistula management worldwide, we herein aim to share our mesenchymal stem cell surgical protocol. With the goal of optimizing results of this emerging therapy, we have improved and refined our protocol over the past 17 years of working with stem cells in clinical trials. The protocol consists of nine reproducible steps for mesenchymal stem cell application inside the fistulous tract, and has proven to be safe and effective in several studies, including international phase III clinical trials.
AB - Anal fistula is a challenging condition both for surgeons and patients. Recurrent fistula, Crohn’s disease, or autoimmune disorders add further complexity to this situation. Numerous clinical trials have now demonstrated that cell-based therapy appears to be a good complement to fistulous surgery. As in any new treatment, especially that involving living cells, appropriate application is paramount to achieve optimal outcomes. As stem cell-based treatments are gaining a strong foothold in fistula management worldwide, we herein aim to share our mesenchymal stem cell surgical protocol. With the goal of optimizing results of this emerging therapy, we have improved and refined our protocol over the past 17 years of working with stem cells in clinical trials. The protocol consists of nine reproducible steps for mesenchymal stem cell application inside the fistulous tract, and has proven to be safe and effective in several studies, including international phase III clinical trials.
KW - Mesenchymal stem cells
KW - Perianal fistula
KW - Surgical protocol
UR - http://www.scopus.com/inward/record.url?scp=85051139372&partnerID=8YFLogxK
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U2 - 10.1007/s11605-018-3895-6
DO - 10.1007/s11605-018-3895-6
M3 - Article
C2 - 30066070
AN - SCOPUS:85051139372
SN - 1091-255X
VL - 22
SP - 2003
EP - 2012
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 11
ER -