A simplified scoring system in de novo follicular lymphoma treated initially with immunochemotherapy

Emmanuel Bachy, Matthew J. Maurer, Thomas M. Habermann, Bénédicte Gelas-Dore, Delphine Maucort-Boulch, Jane A. Estell, Eric Van den Neste, Réda Bouabdallah, Emmanuel Gyan, Andrew L. Feldman, Joan Bargay, Alain Delmer, Susan L. Slager, Maria Gomes da Silva, Olivier Fitoussi, David Belada, Hervé Maisonneuve, Tanin Intragumtornchai, Stephen M. Ansell, Thierry LamyPeggy Dartigues, Brian K. Link, John F. Seymour, James R. Cerhan, Gilles Salles

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

In follicular lymphoma (FL), no prognostic index has been built based solely on a cohort of patients treated with initial immunochemotherapy. There is currently a need to define parsimonious clinical models for trial stratification and to add on biomolecular factors. Here, we confirmed the validity of both the follicular lymphoma international prognostic index (FLIPI) and the FLIPI2 in the large prospective PRIMA trial cohort of 1135 patients treated with initial R-chemotherapy 6 R maintenance. Furthermore, we developed a new prognostic tool comprising only 2 simple parameters (bone marrow involvement and b2-microglobulin [b2m]) to predict progression-free survival (PFS). The final simplified score, called the PRIMA-PI (PRIMA-prognostic index), comprised 3 risk categories: high (b2m > 3 mg/L), low (b2m £ 3 mg/L without bone marrow involvement), and intermediate (b2m £ 3 mg/L with bone marrow involvement). Five-year PFS rates were 69%, 55%, and 37% in the low-, intermediate-, and high-risk groups, respectively (P < .0001). In addition, achieving event-free survival (EFS) or not at 24 months (EFS24) was a strong posttreatment prognostic parameter for subsequent overall survival, and the PRIMA-PI was correlated with EFS24. The results were confirmed in a pooled external validation cohort of 479 patients from the FL2000 LYSA trial and the University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence Molecular Epidemiology Resource. Five-year EFS in the validation cohort was 77%, 57%, and 44% in the PRIMA-PI low-, intermediate-, and high-risk groups, respectively (P < .0001). The PRIMA-PI is a novel and easy-to-compute prognostic index for patients initially treated with immunochemotherapy. This could serve as a basis for building more sophisticated and integrated biomolecular scores.

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalBlood
Volume132
Issue number1
DOIs
StatePublished - Jul 5 2018

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Bachy, E., Maurer, M. J., Habermann, T. M., Gelas-Dore, B., Maucort-Boulch, D., Estell, J. A., Van den Neste, E., Bouabdallah, R., Gyan, E., Feldman, A. L., Bargay, J., Delmer, A., Slager, S. L., da Silva, M. G., Fitoussi, O., Belada, D., Maisonneuve, H., Intragumtornchai, T., Ansell, S. M., ... Salles, G. (2018). A simplified scoring system in de novo follicular lymphoma treated initially with immunochemotherapy. Blood, 132(1), 49-58. https://doi.org/10.1182/blood-2017-11-816405