A self-assembling lanthanide molecular nanoparticle for optical imaging

Katherine A. Brown, Xiaoping Yang, Desmond Schipper, Justin W. Hall, Lauren J. Depue, Annie J. Gnanam, Jonathan F. Arambula, Jessica N. Jones, Jagannath Swaminathan, Yakhya Dieye, Jamuna Vadivelu, Don J. Chandler, Edward M. Marcotte, Jonathan L. Sessler, Lauren I.R. Ehrlich, Richard A. Jones

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Chromophores that incorporate f-block elements have considerable potential for use in bioimaging applications because of their advantageous photophysical properties compared to organic dye, which are currently widely used. We are developing new classes of lanthanide-based self-assembling molecular nanoparticles as reporters for imaging and as multi-functional nanoprobes or nanosensors for use with biological samples. One class of these materials, which we call lanthanide "nano-drums", are homogeneous 4d-4f clusters approximately 25 to 30 Å in diameter. These are capable of emitting from the visible to near-infrared wavelengths. Here, we present the synthesis, crystal structure, photophysical properties and comparative cytotoxicity data for a 32 metal Eu-Cd nano-drum [Eu8Cd24L12(OAc)48] (1). We also explored the imaging capabilities of this nano-drum using epifluorescence, TIRF, and two-photon microscopy platforms.

Original languageEnglish (US)
Pages (from-to)2667-2675
Number of pages9
JournalDalton Transactions
Volume44
Issue number6
DOIs
StatePublished - Jan 28 2015

ASJC Scopus subject areas

  • Inorganic Chemistry

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