A selective sweep across species boundaries in Drosophila

Cara L. Brand, Sarah B. Kingan, LongJun Wu, Daniel Garrigan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Adaptive mutations that accumulate during species divergence are likely to contribute to reproductive incompatibilities and hinder gene flow; however, there may also be a class of mutations that are generally advantageous and can spread across species boundaries. In this study, we characterize a 15 kb region on chromosome 3R that has introgressed from the cosmopolitan generalist species Drosophila simulans into the island endemic D. sechellia, which is an ecological specialist. The introgressed haplotype is fixed in D. sechellia over almost the entirety of the resequenced region, whereas a core region of the introgressed haplotype occurs at high frequency in D. simulans. The observed patterns of nucleotide variation and linkage disequilibrium are consistent with a recently completed selective sweep in D. sechellia and an incomplete sweep in D. simulans. Independent estimates of both the time to the introgression and sweep events are all close to 10,000 years before the present. Interestingly, the most likely target of selection is a highly occupied transcription factor binding region. This work confirms that it is possible for mutations to be globally advantageous, despite their occurrence in divergent genomic and ecological backgrounds.

Original languageEnglish (US)
Pages (from-to)2177-2186
Number of pages10
JournalMolecular Biology and Evolution
Volume30
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Drosophila simulans
Drosophila sechellia
Drosophila
mutation
Haplotypes
Mutation
haplotypes
Gene Flow
Linkage Disequilibrium
linkage disequilibrium
Islands
introgression
incompatibility
gene flow
Transcription Factors
Nucleotides
transcription factors
Chromosomes
nucleotides
generalist

Keywords

  • adaptive evolution
  • Drosophila sechellia
  • Drosophila simulans
  • introgression
  • polymorphism
  • speciation

ASJC Scopus subject areas

  • Medicine(all)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

A selective sweep across species boundaries in Drosophila. / Brand, Cara L.; Kingan, Sarah B.; Wu, LongJun; Garrigan, Daniel.

In: Molecular Biology and Evolution, Vol. 30, No. 9, 01.09.2013, p. 2177-2186.

Research output: Contribution to journalArticle

Brand, Cara L. ; Kingan, Sarah B. ; Wu, LongJun ; Garrigan, Daniel. / A selective sweep across species boundaries in Drosophila. In: Molecular Biology and Evolution. 2013 ; Vol. 30, No. 9. pp. 2177-2186.
@article{015b02d714b643ef96a25a1720ff00f6,
title = "A selective sweep across species boundaries in Drosophila",
abstract = "Adaptive mutations that accumulate during species divergence are likely to contribute to reproductive incompatibilities and hinder gene flow; however, there may also be a class of mutations that are generally advantageous and can spread across species boundaries. In this study, we characterize a 15 kb region on chromosome 3R that has introgressed from the cosmopolitan generalist species Drosophila simulans into the island endemic D. sechellia, which is an ecological specialist. The introgressed haplotype is fixed in D. sechellia over almost the entirety of the resequenced region, whereas a core region of the introgressed haplotype occurs at high frequency in D. simulans. The observed patterns of nucleotide variation and linkage disequilibrium are consistent with a recently completed selective sweep in D. sechellia and an incomplete sweep in D. simulans. Independent estimates of both the time to the introgression and sweep events are all close to 10,000 years before the present. Interestingly, the most likely target of selection is a highly occupied transcription factor binding region. This work confirms that it is possible for mutations to be globally advantageous, despite their occurrence in divergent genomic and ecological backgrounds.",
keywords = "adaptive evolution, Drosophila sechellia, Drosophila simulans, introgression, polymorphism, speciation",
author = "Brand, {Cara L.} and Kingan, {Sarah B.} and LongJun Wu and Daniel Garrigan",
year = "2013",
month = "9",
day = "1",
doi = "10.1093/molbev/mst123",
language = "English (US)",
volume = "30",
pages = "2177--2186",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - A selective sweep across species boundaries in Drosophila

AU - Brand, Cara L.

AU - Kingan, Sarah B.

AU - Wu, LongJun

AU - Garrigan, Daniel

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Adaptive mutations that accumulate during species divergence are likely to contribute to reproductive incompatibilities and hinder gene flow; however, there may also be a class of mutations that are generally advantageous and can spread across species boundaries. In this study, we characterize a 15 kb region on chromosome 3R that has introgressed from the cosmopolitan generalist species Drosophila simulans into the island endemic D. sechellia, which is an ecological specialist. The introgressed haplotype is fixed in D. sechellia over almost the entirety of the resequenced region, whereas a core region of the introgressed haplotype occurs at high frequency in D. simulans. The observed patterns of nucleotide variation and linkage disequilibrium are consistent with a recently completed selective sweep in D. sechellia and an incomplete sweep in D. simulans. Independent estimates of both the time to the introgression and sweep events are all close to 10,000 years before the present. Interestingly, the most likely target of selection is a highly occupied transcription factor binding region. This work confirms that it is possible for mutations to be globally advantageous, despite their occurrence in divergent genomic and ecological backgrounds.

AB - Adaptive mutations that accumulate during species divergence are likely to contribute to reproductive incompatibilities and hinder gene flow; however, there may also be a class of mutations that are generally advantageous and can spread across species boundaries. In this study, we characterize a 15 kb region on chromosome 3R that has introgressed from the cosmopolitan generalist species Drosophila simulans into the island endemic D. sechellia, which is an ecological specialist. The introgressed haplotype is fixed in D. sechellia over almost the entirety of the resequenced region, whereas a core region of the introgressed haplotype occurs at high frequency in D. simulans. The observed patterns of nucleotide variation and linkage disequilibrium are consistent with a recently completed selective sweep in D. sechellia and an incomplete sweep in D. simulans. Independent estimates of both the time to the introgression and sweep events are all close to 10,000 years before the present. Interestingly, the most likely target of selection is a highly occupied transcription factor binding region. This work confirms that it is possible for mutations to be globally advantageous, despite their occurrence in divergent genomic and ecological backgrounds.

KW - adaptive evolution

KW - Drosophila sechellia

KW - Drosophila simulans

KW - introgression

KW - polymorphism

KW - speciation

UR - http://www.scopus.com/inward/record.url?scp=84883225153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883225153&partnerID=8YFLogxK

U2 - 10.1093/molbev/mst123

DO - 10.1093/molbev/mst123

M3 - Article

VL - 30

SP - 2177

EP - 2186

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 9

ER -