TY - JOUR
T1 - A score to identify patients with brain metastases from colorectal cancer who may benefit from whole-brain radiotherapy in addition to stereotactic radiosurgery/radiotherapy
AU - Rades, Dirk
AU - Dziggel, Liesa
AU - Blanck, Oliver
AU - Gebauer, Niklas
AU - Bartscht, Tobias
AU - Schild, Steven E.
N1 - Publisher Copyright:
© 2018 International Institute of Anticancer Research. All rights reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Aim: To design a tool to predict the probability of new cerebral lesions after stereotactic radiosurgery/radiotherapy for patients with 1-3 brain metastases from colorectal cancer. Patients and Methods: In 21 patients, nine factors were evaluated for freedom from new brain metastases, namely age, gender, Karnofsky performance score (KPS), tumor type, number, maximum total diameter of all lesions and sites of cerebral lesions, extra-cranial metastases, and time from cancer diagnosis to irradiation. Results: Freedom from new lesions was positively associated with KPS of 90-100 (p=0.013); maximum total diameter ≤15 mm showed a trend for positive association (p=0.09). Points were assigned as: KPS 70-80=1 point, KPS 90-100=2 points, maximum diameter ≤15 mm=2 points and maximum diameter >15 mm=1 point. Six-month rates of freedom from new lesions were 29%, 45% and 100% for those with total scores of 2, 3 and 4 points, respectively, with corresponding 12-month rates of 0%, 45% and 100% (p=0.027). Conclusion: This study identified three risk groups regarding new brain metastases after stereotactic irradiation. Patients with 2 points could benefit from additional whole-brain radiotherapy.
AB - Aim: To design a tool to predict the probability of new cerebral lesions after stereotactic radiosurgery/radiotherapy for patients with 1-3 brain metastases from colorectal cancer. Patients and Methods: In 21 patients, nine factors were evaluated for freedom from new brain metastases, namely age, gender, Karnofsky performance score (KPS), tumor type, number, maximum total diameter of all lesions and sites of cerebral lesions, extra-cranial metastases, and time from cancer diagnosis to irradiation. Results: Freedom from new lesions was positively associated with KPS of 90-100 (p=0.013); maximum total diameter ≤15 mm showed a trend for positive association (p=0.09). Points were assigned as: KPS 70-80=1 point, KPS 90-100=2 points, maximum diameter ≤15 mm=2 points and maximum diameter >15 mm=1 point. Six-month rates of freedom from new lesions were 29%, 45% and 100% for those with total scores of 2, 3 and 4 points, respectively, with corresponding 12-month rates of 0%, 45% and 100% (p=0.027). Conclusion: This study identified three risk groups regarding new brain metastases after stereotactic irradiation. Patients with 2 points could benefit from additional whole-brain radiotherapy.
KW - Brain metastases
KW - Colorectal cancer
KW - Fractionated stereotactic radiotherapy
KW - New brain metastases
KW - Prognostic score
KW - Stereotactic radiosurgery
KW - Whole-brain radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85046507432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046507432&partnerID=8YFLogxK
U2 - 10.21873/anticanres.12570
DO - 10.21873/anticanres.12570
M3 - Article
C2 - 29715148
AN - SCOPUS:85046507432
SN - 0250-7005
VL - 38
SP - 3111
EP - 3114
JO - Anticancer research
JF - Anticancer research
IS - 5
ER -