A role for the survival of motor neuron protein in mRNP assembly and transport

Paul G. Donlin-Asp; Gary J. Bassell; Wilfried Rossoll

doi:10.1016/j.conb.2016.04.004

A role for the survival of motor neuron protein in mRNP assembly and transport

Paul G. Donlin-Asp, Gary J. Bassell, Wilfried Rossoll

Neuroscience

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Localization and local translation of mRNA plays a key role in neuronal development and function. While studies in various systems have provided insights into molecular mechanisms of mRNA transport and local protein synthesis, the factors that control the assembly of mRNAs and mRNA binding proteins into messenger ribonucleoprotein (mRNP) transport granules remain largely unknown. In this review we will discuss how insights on a motor neuron disease, spinal muscular atrophy (SMA), is advancing our understanding of regulated assembly of transport competent mRNPs and how defects in their assembly and delivery may contribute to the degeneration of motor neurons observed in SMA and other neurological disorders.

Original language	English (US)
Pages (from-to)	53-61
Number of pages	9
Journal	Current Opinion in Neurobiology
Volume	39
DOIs	https://doi.org/10.1016/j.conb.2016.04.004
State	Published - Aug 1 2016

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.conb.2016.04.004

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title = "A role for the survival of motor neuron protein in mRNP assembly and transport",

abstract = "Localization and local translation of mRNA plays a key role in neuronal development and function. While studies in various systems have provided insights into molecular mechanisms of mRNA transport and local protein synthesis, the factors that control the assembly of mRNAs and mRNA binding proteins into messenger ribonucleoprotein (mRNP) transport granules remain largely unknown. In this review we will discuss how insights on a motor neuron disease, spinal muscular atrophy (SMA), is advancing our understanding of regulated assembly of transport competent mRNPs and how defects in their assembly and delivery may contribute to the degeneration of motor neurons observed in SMA and other neurological disorders.",

author = "Donlin-Asp, {Paul G.} and Bassell, {Gary J.} and Wilfried Rossoll",

note = "Funding Information: This work was supported by the Muscular Dystrophy Association (MDA) and Weisman Family Foundation to GJB; the US National Institute of Health (NIH) Grant NS091749 to WR; the National Research Service Award (NRSA) training grant F31NS084730-01 and ARCS Fellowship Roche Foundation award to PGDA. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

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N2 - Localization and local translation of mRNA plays a key role in neuronal development and function. While studies in various systems have provided insights into molecular mechanisms of mRNA transport and local protein synthesis, the factors that control the assembly of mRNAs and mRNA binding proteins into messenger ribonucleoprotein (mRNP) transport granules remain largely unknown. In this review we will discuss how insights on a motor neuron disease, spinal muscular atrophy (SMA), is advancing our understanding of regulated assembly of transport competent mRNPs and how defects in their assembly and delivery may contribute to the degeneration of motor neurons observed in SMA and other neurological disorders.

AB - Localization and local translation of mRNA plays a key role in neuronal development and function. While studies in various systems have provided insights into molecular mechanisms of mRNA transport and local protein synthesis, the factors that control the assembly of mRNAs and mRNA binding proteins into messenger ribonucleoprotein (mRNP) transport granules remain largely unknown. In this review we will discuss how insights on a motor neuron disease, spinal muscular atrophy (SMA), is advancing our understanding of regulated assembly of transport competent mRNPs and how defects in their assembly and delivery may contribute to the degeneration of motor neurons observed in SMA and other neurological disorders.

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A role for the survival of motor neuron protein in mRNP assembly and transport

Abstract

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