A role for calcium in radiocontrast-induced reductions in renal hemodynamics

G. L. Bakris, John C Jr. Burnett

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Abstract

Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalKidney International
Volume27
Issue number2
StatePublished - 1985

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ASJC Scopus subject areas

  • Nephrology

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