A role for calcium in radiocontrast-induced reductions in renal hemodynamics

G. L. Bakris; J. C. Burnett

doi:10.1038/ki.1985.32

A role for calcium in radiocontrast-induced reductions in renal hemodynamics

G. L. Bakris, J. C. Burnett

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.

Original language	English (US)
Pages (from-to)	465-468
Number of pages	4
Journal	Kidney international
Volume	27
Issue number	2
DOIs	https://doi.org/10.1038/ki.1985.32
State	Published - 1985

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1985.32

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abstract = "Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.",

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A role for calcium in radiocontrast-induced reductions in renal hemodynamics

Abstract

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