Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1985|
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