@article{62692d22e6e54aefad719355fc67c719,
title = "A role for calcium in radiocontrast-induced reductions in renal hemodynamics",
abstract = "Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.",
author = "Bakris, {G. L.} and Burnett, {J. C.}",
note = "Funding Information: 80sponse to vasoconstrictor stimuli. Intrarenal administration of support the importance of calcium in radiocontrast-mediated GFiRn/,g mkidi/nreny radiocontrast medium is well known to cause decrements in changes in renal hemodynamics. 060RBF and GFR; these responses may depend on the availability o 400Verapamil groupof the calcium ion [2, 3, 8, 13]. We postulated that alterations in Acknowledgments 0Co1n0t..r000o.025.60l55{"} calcium ion would attenuate the vasoconstrictive response and 2Verapamil000..800.0375.064 blunt the decrement in GFR associated with radiocontrast CDCmedium administration. 83964 awarded to Dr. J. C. Burnett, Jr., as well as the Rappaport and *Diltiazem groupOur experiments demonstrate that calcium antagonism withInstitutes of Health Hypertension Training Grant HL07269. The au- 50Co1n0t..r000o.036.30l17{"} thors thank M. Onsgard and J. Haas for technical and laboratoryMayo Foundations. Dr. G. L. Bakris is supported by the National 5-10Dilt0i0a.z.8e00.0m678.161 verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of and J. M. Hanke for secretarial assistance in preparing this manuscript.assistance, Marion Laboratories for its generous donation of diltiazem,",
year = "1985",
doi = "10.1038/ki.1985.32",
language = "English (US)",
volume = "27",
pages = "465--468",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "2",
}