Abstract
Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-468 |
| Number of pages | 4 |
| Journal | Kidney International |
| Volume | 27 |
| Issue number | 2 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Nephrology
Cite this
A role for calcium in radiocontrast-induced reductions in renal hemodynamics. / Bakris, G. L.; Burnett, John C Jr.
In: Kidney International, Vol. 27, No. 2, 1985, p. 465-468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A role for calcium in radiocontrast-induced reductions in renal hemodynamics
AU - Bakris, G. L.
AU - Burnett, John C Jr.
PY - 1985
Y1 - 1985
N2 - Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.
AB - Our experiments in dogs demonstrate that calcium antagonism with verapamil or diltiazem or chelation of calcium with EGTA yield a significant attenuation in the magnitude and duration of radiocontrast-mediated intrarenal vasoconstriction. Furthermore, these pharmacologic maneuvers accentuate the initial period of vasodilation associated with radiocontrast medium administration. These hemodynamic responses were achieved at intrarenal doses which did not alter systemic arterial pressure or baseline RBF.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021945823&partnerID=8YFLogxK
M3 - Article
C2 - 2581011
AN - SCOPUS:0021945823
VL - 27
SP - 465
EP - 468
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 2
ER -