A role for BLyS in the activation of innate immune cells

Kyung Chang Sook, Bonnie K. Arendt, Jaime R. Darce, Xiaosheng Wu, Diane F. Jelinek

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily. Although BLyS costimulates adaptive immune cells, the ability of BLyS to stimulate innate immune cells has not been described. Here, we show that BLyS strongly induces human monocyte survival, and activation as measured by proinflammatory cytokine secretion and up-regulation of costimulatory molecule expression. In addition, monocytes cultured with BLyS differentiated into macrophage-like cells. Regarding BLyS receptor(s) expression, freshly isolated monocytes bound low levels of exogenous BLyS and expressed primarily intracellular TACI, and cell surface TACI levels increased following monocyte activation. Of interest, bone marrow monocytes from some multiple myeloma patients expressed significant levels of cell surface TACI at isolation. Our findings indicate that BLyS plays a role in activating innate immune cells. Moreover, this study may explain more clearly why high BLyS production is often correlated with certain inflammatory autoimmune diseases and B-lymphocyte malignancies.

Original languageEnglish (US)
Pages (from-to)2687-2694
Number of pages8
JournalBlood
Volume108
Issue number8
DOIs
StatePublished - Oct 15 2006

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'A role for BLyS in the activation of innate immune cells'. Together they form a unique fingerprint.

  • Cite this