A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network

Suzette J. Bielinski, Jyotishman Pathak, David S. Carrell, Paul Y. Takahashi, Janet E. Olson, Nicholas B. Larson, Hongfang Liu, Sunghwan Sohn, Quinn S. Wells, Joshua C. Denny, Laura J. Rasmussen-Torvik, Jennifer Allen Pacheco, Kathryn L. Jackson, Timothy G. Lesnick, Rachel E. Gullerud, Paul A. Decker, Naveen L. Pereira, Euijung Ryu, Richard A. Dart, Peggy PeissigJames G. Linneman, Gail P. Jarvik, Eric B. Larson, Jonathan A. Bock, Gerard C. Tromp, Mariza de Andrade, Véronique L. Roger

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Identifying populations of heart failure (HF) patients is paramount to research efforts aimed at developing strategies to effectively reduce the burden of this disease. The use of electronic medical record (EMR) data for this purpose is challenging given the syndromic nature of HF and the need to distinguish HF with preserved or reduced ejection fraction. Using a gold standard cohort of manually abstracted cases, an EMR-driven phenotype algorithm based on structured and unstructured data was developed to identify all the cases. The resulting algorithm was executed in two cohorts from the Electronic Medical Records and Genomics (eMERGE) Network with a positive predictive value of >95 %. The algorithm was expanded to include three hierarchical definitions of HF (i.e., definite, probable, possible) based on the degree of confidence of the classification to capture HF cases in a whole population whereby increasing the algorithm utility for use in e-Epidemiologic research.

Original languageEnglish (US)
Pages (from-to)475-483
Number of pages9
JournalJournal of cardiovascular translational research
Volume8
Issue number8
DOIs
StatePublished - Nov 1 2015

Keywords

  • Electronic medical records
  • Heart failure
  • Natural language processing
  • Phenotyping
  • Ventricular ejection fraction

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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