A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network

Suzette J Bielinski, Jyotishman Pathak, David S. Carrell, Paul Y Takahashi, Janet E Olson, Nicholas Larson, Hongfang D Liu, Sunghwan Sohn, Quinn S. Wells, Joshua C. Denny, Laura J. Rasmussen-Torvik, Jennifer Allen Pacheco, Kathryn L. Jackson, Timothy G. Lesnick, Rachel E. Gullerud, Paul A. Decker, Naveen Luke Pereira, Euijung Ryu, Richard A. Dart, Peggy PeissigJames G. Linneman, Gail P. Jarvik, Eric B. Larson, Jonathan A. Bock, Gerard C. Tromp, Mariza De Andrade, Veronique Lee Roger

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Identifying populations of heart failure (HF) patients is paramount to research efforts aimed at developing strategies to effectively reduce the burden of this disease. The use of electronic medical record (EMR) data for this purpose is challenging given the syndromic nature of HF and the need to distinguish HF with preserved or reduced ejection fraction. Using a gold standard cohort of manually abstracted cases, an EMR-driven phenotype algorithm based on structured and unstructured data was developed to identify all the cases. The resulting algorithm was executed in two cohorts from the Electronic Medical Records and Genomics (eMERGE) Network with a positive predictive value of >95 %. The algorithm was expanded to include three hierarchical definitions of HF (i.e., definite, probable, possible) based on the degree of confidence of the classification to capture HF cases in a whole population whereby increasing the algorithm utility for use in e-Epidemiologic research.

Original languageEnglish (US)
JournalJournal of Cardiovascular Translational Research
DOIs
StateAccepted/In press - Jul 21 2015

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Keywords

  • Electronic medical records
  • Heart failure
  • Natural language processing
  • Phenotyping
  • Ventricular ejection fraction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

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