A Review on the Surgical Management of Insular Gliomas

Jaclyn J. Renfrow, Bao Quynh Julian, Desmond A. Brown, Stephen B. Tatter, Adrian W. Laxton, Glenn J. Lesser, Roy E. Strowd, Ian F. Parney

Research output: Contribution to journalReview articlepeer-review


The surgical treatment of insular gliomas requires specialized knowledge. Over the last three decades, increased momentum in surgical resection of insular gliomas shifted the focus from one of expectant management to maximal safe resection to establish a diagnosis, characterize tumor genetics, treat pre-operative symptoms (i.e. seizures), and to delay malignant transformation through tumor cytoreduction. A comprehensive review of the literature was performed regarding insular glioma classification/genetics, insular anatomy, surgical approaches, and patient outcomes. Modern large, published series of insular resections have reported a median 80% resection, 80% improvement in preoperative seizures, and post-surgical permanent neurologic deficits of less than 10%. Major complication avoidance includes recognition and preservation of eloquent cortex for language and respecting the lateral lenticulostriate arteries.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalCanadian Journal of Neurological Sciences
StateAccepted/In press - 2021


  • Brain Tumor
  • Glioblastoma
  • Gliomas
  • High-grade Glioma
  • Insula
  • Low-Grade Glioma
  • Neuroanatomy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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