A review of mortality and surgery in ulcerative colitis

Milestones of the seriousness of the disease

Charles N. Bernstein, Siew C. Ng, Peter L. Lakatos, Bjorn Moum, Edward Vincent Loftus, Jr

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Standardized mortality rates in ulcerative colitis (UC) are no different than that in the general population. Patients who are older and have more comorbidities have increased mortality. Emergent colectomy still carries 30-day mortality rates of approximately 5%. In more recent studies, UC surgery rates at 10 years from diagnosis are nearly 3% in Hungary, <10% in referral center studies from Asia, approximately 10% in Norway, the European Cohort Study of Inflammatory Bowel Diseases and Manitoba, Canada, and nearly 17% in Olmsted County, Minnesota. These rates are for the most part lower than reported colectomy rates from studies completed before 1990. Short-term colectomy rates in severe hospitalized UC have remained stable at 27% for several years. Generally, children seem to have higher rates of extensive colitis at diagnosis than adults. There also seems to be higher rates of colectomy in children than in adults (i.e., at least 20% at 10 years), and perhaps, this reflects a higher rate of extensive disease. Acute severe colitis in patients with UC still represents a condition with a high early colectomy rate and a measurable mortality rate.

Original languageEnglish (US)
Pages (from-to)2001-2010
Number of pages10
JournalInflammatory Bowel Diseases
Volume19
Issue number9
DOIs
StatePublished - Aug 2013

Fingerprint

Colectomy
Ulcerative Colitis
Mortality
Colitis
Manitoba
Hungary
Norway
Inflammatory Bowel Diseases
Canada
Comorbidity
Cohort Studies
Referral and Consultation
Population

Keywords

  • Hospitalization
  • Mortality
  • Natural history
  • Surgery
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

A review of mortality and surgery in ulcerative colitis : Milestones of the seriousness of the disease. / Bernstein, Charles N.; Ng, Siew C.; Lakatos, Peter L.; Moum, Bjorn; Loftus, Jr, Edward Vincent.

In: Inflammatory Bowel Diseases, Vol. 19, No. 9, 08.2013, p. 2001-2010.

Research output: Contribution to journalArticle

Bernstein, Charles N. ; Ng, Siew C. ; Lakatos, Peter L. ; Moum, Bjorn ; Loftus, Jr, Edward Vincent. / A review of mortality and surgery in ulcerative colitis : Milestones of the seriousness of the disease. In: Inflammatory Bowel Diseases. 2013 ; Vol. 19, No. 9. pp. 2001-2010.
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