TY - JOUR
T1 - A replicating module as the unit of mitochondrial structure and functioning
AU - Capaldi, Roderick A.
AU - Aggeler, Robert
AU - Gilkerson, Robert
AU - Hanson, George
AU - Knowles, Michelle
AU - Marcus, Andrew
AU - Margineantu, Daciana
AU - Marusich, Michael
AU - Murray, James
AU - Oglesbee, Devin
AU - Remington, S. James
AU - Rossignol, Rodrigue
PY - 2002/9/10
Y1 - 2002/9/10
N2 - The mitochondrion within human cells in tissue culture is pleomorphic and highly dynamic. The organelle mass can exist as thousands of small ovoids or as one continuous reticulum. In either state, the mitochondrial mass is in constant thermal motion, as well as moving in ≃0.8-μm jumps that are determined by, and related to, attachments with cytoskeletal elements. Many protein complexes, such as the pyruvate dehydrogenase (PDH) complex and DNA containing nucleoids, are dispersed through the mass and as though fixed by attachments to membranes, such that they can become distributed to all of the individual small ovoid mitochondria when the reticulum becomes fragmented. This leads us to propose that a replicating module is the repeating unit of mitochondrial structure. Studies to examine heterogeneity of functioning within the organelle mass are briefly reviewed.
AB - The mitochondrion within human cells in tissue culture is pleomorphic and highly dynamic. The organelle mass can exist as thousands of small ovoids or as one continuous reticulum. In either state, the mitochondrial mass is in constant thermal motion, as well as moving in ≃0.8-μm jumps that are determined by, and related to, attachments with cytoskeletal elements. Many protein complexes, such as the pyruvate dehydrogenase (PDH) complex and DNA containing nucleoids, are dispersed through the mass and as though fixed by attachments to membranes, such that they can become distributed to all of the individual small ovoid mitochondria when the reticulum becomes fragmented. This leads us to propose that a replicating module is the repeating unit of mitochondrial structure. Studies to examine heterogeneity of functioning within the organelle mass are briefly reviewed.
KW - Mitochondrion
KW - Replicating module
KW - Structure-function relationship
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U2 - 10.1016/S0005-2728(02)00277-3
DO - 10.1016/S0005-2728(02)00277-3
M3 - Article
C2 - 12206914
AN - SCOPUS:11144355144
SN - 0005-2728
VL - 1555
SP - 192
EP - 195
JO - Biochimica et Biophysica Acta - Bioenergetics
JF - Biochimica et Biophysica Acta - Bioenergetics
IS - 1-3
ER -