A regulatory monoamine oxidase A promoter polymorphism and personality traits

Håkan Garpenstrand, Nadine Norton, Mattias Damberg, Gunnar Rylander, Kaj Forslund, Marja Mattila-Evenden, J. Petter Gustavsson, Jonas Ekblom, Lars Oreland, Hans Bergman, Michael J. Owen, Erik G. Jönsson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders. We hypothesised that a functional polymorphism in the 5′ untranslated region of the MAOA gene is associated with specific personality traits. In 371 healthy Caucasians, we estimated personality traits by the use of the Karolinska Scales of Personality (KSP), Scandinavian Universities Scales of Personality, Health-Relevant 5-Factor Personality inventory, Temperament and Character Inventory and the revised NEO Personality Inventory. In the same subjects, we analysed the genotype of a polymorphic region consisting of a variable number of a 30-bp repeat sequence located approximately 1.2 kb upstream of the MAOA gene. After correction for multiple testing, no statistically significant differences between MAOA genotype and personality were observed in men (n = 206) nor in women (n = 165). We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalNeuropsychobiology
Volume46
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Monoamine Oxidase
Personality
Personality Inventory
Temperament
Type A Personality
Genotype
5' Untranslated Regions
Genetic Promoter Regions
Genes
Psychiatry
Equipment and Supplies
Health
Population

Keywords

  • Amino oxidase
  • Candidate gene
  • Monoamine oxidase A
  • Personality
  • Polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Garpenstrand, H., Norton, N., Damberg, M., Rylander, G., Forslund, K., Mattila-Evenden, M., ... Jönsson, E. G. (2002). A regulatory monoamine oxidase A promoter polymorphism and personality traits. Neuropsychobiology, 46(4), 190-193. https://doi.org/10.1159/000067804

A regulatory monoamine oxidase A promoter polymorphism and personality traits. / Garpenstrand, Håkan; Norton, Nadine; Damberg, Mattias; Rylander, Gunnar; Forslund, Kaj; Mattila-Evenden, Marja; Gustavsson, J. Petter; Ekblom, Jonas; Oreland, Lars; Bergman, Hans; Owen, Michael J.; Jönsson, Erik G.

In: Neuropsychobiology, Vol. 46, No. 4, 2002, p. 190-193.

Research output: Contribution to journalArticle

Garpenstrand, H, Norton, N, Damberg, M, Rylander, G, Forslund, K, Mattila-Evenden, M, Gustavsson, JP, Ekblom, J, Oreland, L, Bergman, H, Owen, MJ & Jönsson, EG 2002, 'A regulatory monoamine oxidase A promoter polymorphism and personality traits', Neuropsychobiology, vol. 46, no. 4, pp. 190-193. https://doi.org/10.1159/000067804
Garpenstrand H, Norton N, Damberg M, Rylander G, Forslund K, Mattila-Evenden M et al. A regulatory monoamine oxidase A promoter polymorphism and personality traits. Neuropsychobiology. 2002;46(4):190-193. https://doi.org/10.1159/000067804
Garpenstrand, Håkan ; Norton, Nadine ; Damberg, Mattias ; Rylander, Gunnar ; Forslund, Kaj ; Mattila-Evenden, Marja ; Gustavsson, J. Petter ; Ekblom, Jonas ; Oreland, Lars ; Bergman, Hans ; Owen, Michael J. ; Jönsson, Erik G. / A regulatory monoamine oxidase A promoter polymorphism and personality traits. In: Neuropsychobiology. 2002 ; Vol. 46, No. 4. pp. 190-193.
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