A regulatory monoamine oxidase A promoter polymorphism and personality traits

Håkan Garpenstrand; Nadine Norton; Mattias Damberg; Gunnar Rylander; Kaj Forslund; Marja Mattila-Evenden; J. Petter Gustavsson; Jonas Ekblom; Lars Oreland; Hans Bergman; Michael J. Owen; Erik G. Jönsson

doi:10.1159/000067804

A regulatory monoamine oxidase A promoter polymorphism and personality traits

Håkan Garpenstrand, Nadine Norton, Mattias Damberg, Gunnar Rylander, Kaj Forslund, Marja Mattila-Evenden, J. Petter Gustavsson, Jonas Ekblom, Lars Oreland, Hans Bergman, Michael J. Owen, Erik G. Jönsson

Cancer Biology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders. We hypothesised that a functional polymorphism in the 5′ untranslated region of the MAOA gene is associated with specific personality traits. In 371 healthy Caucasians, we estimated personality traits by the use of the Karolinska Scales of Personality (KSP), Scandinavian Universities Scales of Personality, Health-Relevant 5-Factor Personality inventory, Temperament and Character Inventory and the revised NEO Personality Inventory. In the same subjects, we analysed the genotype of a polymorphic region consisting of a variable number of a 30-bp repeat sequence located approximately 1.2 kb upstream of the MAOA gene. After correction for multiple testing, no statistically significant differences between MAOA genotype and personality were observed in men (n = 206) nor in women (n = 165). We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.

Original language	English (US)
Pages (from-to)	190-193
Number of pages	4
Journal	Neuropsychobiology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1159/000067804
State	Published - 2002

Keywords

Amino oxidase
Candidate gene
Monoamine oxidase A
Personality
Polymorphism

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

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abstract = "Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders. We hypothesised that a functional polymorphism in the 5′ untranslated region of the MAOA gene is associated with specific personality traits. In 371 healthy Caucasians, we estimated personality traits by the use of the Karolinska Scales of Personality (KSP), Scandinavian Universities Scales of Personality, Health-Relevant 5-Factor Personality inventory, Temperament and Character Inventory and the revised NEO Personality Inventory. In the same subjects, we analysed the genotype of a polymorphic region consisting of a variable number of a 30-bp repeat sequence located approximately 1.2 kb upstream of the MAOA gene. After correction for multiple testing, no statistically significant differences between MAOA genotype and personality were observed in men (n = 206) nor in women (n = 165). We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.",

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doi = "10.1159/000067804",

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AU - Garpenstrand, Håkan

AU - Norton, Nadine

AU - Damberg, Mattias

AU - Rylander, Gunnar

AU - Forslund, Kaj

AU - Mattila-Evenden, Marja

AU - Gustavsson, J. Petter

AU - Ekblom, Jonas

AU - Oreland, Lars

AU - Bergman, Hans

AU - Owen, Michael J.

AU - Jönsson, Erik G.

PY - 2002

Y1 - 2002

N2 - Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders. We hypothesised that a functional polymorphism in the 5′ untranslated region of the MAOA gene is associated with specific personality traits. In 371 healthy Caucasians, we estimated personality traits by the use of the Karolinska Scales of Personality (KSP), Scandinavian Universities Scales of Personality, Health-Relevant 5-Factor Personality inventory, Temperament and Character Inventory and the revised NEO Personality Inventory. In the same subjects, we analysed the genotype of a polymorphic region consisting of a variable number of a 30-bp repeat sequence located approximately 1.2 kb upstream of the MAOA gene. After correction for multiple testing, no statistically significant differences between MAOA genotype and personality were observed in men (n = 206) nor in women (n = 165). We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.

AB - Monoamine oxidase type A (MAOA) has been implicated to be part of mechanisms underlying human temperament and psychiatric disorders. We hypothesised that a functional polymorphism in the 5′ untranslated region of the MAOA gene is associated with specific personality traits. In 371 healthy Caucasians, we estimated personality traits by the use of the Karolinska Scales of Personality (KSP), Scandinavian Universities Scales of Personality, Health-Relevant 5-Factor Personality inventory, Temperament and Character Inventory and the revised NEO Personality Inventory. In the same subjects, we analysed the genotype of a polymorphic region consisting of a variable number of a 30-bp repeat sequence located approximately 1.2 kb upstream of the MAOA gene. After correction for multiple testing, no statistically significant differences between MAOA genotype and personality were observed in men (n = 206) nor in women (n = 165). We conclude that the structure of this MAOA promoter region does not have a large impact on the expression of personality characteristics in the present Swedish population.

KW - Amino oxidase

KW - Candidate gene

KW - Monoamine oxidase A

KW - Personality

KW - Polymorphism

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A regulatory monoamine oxidase A promoter polymorphism and personality traits

Abstract

Keywords

ASJC Scopus subject areas

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