A refined physical map of the long arm of human chromosome 16

L. Z. Chen, Peter C Harris, S. Apostolou, E. Baker, K. Holman, S. A. Lane, J. K. Nancarrow, S. A. Whitmore, R. L. Stallings, C. E. Hildebrand, R. I. Richards, G. R. Sutherland, D. F. Callen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mapping of 33 anonymous DNA probes and 12 genes to the long arm of chromosome 16 was achieved by the use of 14 mouse/human hybrid cell lines and the fragile site FRA16B. Two of the hybrid cell lines contained overlapping interstitial deletions in bands q21 and q22.1. The localization of the 12 genes has been refined. The breakpoints present in the hybrids, in conjunction with the fragile site, can potentially divide the long arm of chromosome 16 into 16 regions. However, this was reduced to 14 regions because in two instances there were no probes or genes that mapped between pairs of breakpoints.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalGenomics
Volume10
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Chromosomes, Human, Pair 16
Hybrid Cells
Human Chromosomes
Cell Line
DNA Probes
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Chen, L. Z., Harris, P. C., Apostolou, S., Baker, E., Holman, K., Lane, S. A., ... Callen, D. F. (1991). A refined physical map of the long arm of human chromosome 16. Genomics, 10(2), 308-312. https://doi.org/10.1016/0888-7543(91)90313-4

A refined physical map of the long arm of human chromosome 16. / Chen, L. Z.; Harris, Peter C; Apostolou, S.; Baker, E.; Holman, K.; Lane, S. A.; Nancarrow, J. K.; Whitmore, S. A.; Stallings, R. L.; Hildebrand, C. E.; Richards, R. I.; Sutherland, G. R.; Callen, D. F.

In: Genomics, Vol. 10, No. 2, 1991, p. 308-312.

Research output: Contribution to journalArticle

Chen, LZ, Harris, PC, Apostolou, S, Baker, E, Holman, K, Lane, SA, Nancarrow, JK, Whitmore, SA, Stallings, RL, Hildebrand, CE, Richards, RI, Sutherland, GR & Callen, DF 1991, 'A refined physical map of the long arm of human chromosome 16', Genomics, vol. 10, no. 2, pp. 308-312. https://doi.org/10.1016/0888-7543(91)90313-4
Chen, L. Z. ; Harris, Peter C ; Apostolou, S. ; Baker, E. ; Holman, K. ; Lane, S. A. ; Nancarrow, J. K. ; Whitmore, S. A. ; Stallings, R. L. ; Hildebrand, C. E. ; Richards, R. I. ; Sutherland, G. R. ; Callen, D. F. / A refined physical map of the long arm of human chromosome 16. In: Genomics. 1991 ; Vol. 10, No. 2. pp. 308-312.
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