A Rare Pediatric Example of Subcutaneous Extraskeletal Osteosarcoma: A Case Report and Review of the Morphologic Differential Diagnosis

Riyam T. Zreik, Reid G. Meyer, Robert Brian Jenkins, Germán A. Norambuena, Karen J. Fritchie

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ABSTRACT:: Primary extraskeletal osteosarcoma is an exceedingly rare malignant neoplasm that accounts for approximately 1% of soft tissue sarcomas and most often occurs in the deep soft tissues of adults. Extraskeletal osteosarcoma is characterized by the production of osteoid, bone, and/or chondroid matrix. The diagnosis of extraskeletal osteosarcoma requires careful radiologic and clinical correlation to ensure that the patient does not have an underlying bone primary. This is a case report of primary subcutaneous extraskeletal osteosarcoma arising in the thigh of a 15-year-old girl with a complex karyotype, and the morphologic differential diagnosis is reviewed.

Original languageEnglish (US)
JournalAmerican Journal of Dermatopathology
StateAccepted/In press - Oct 12 2015


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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