A rare cause of right ventricular failure

Prasad M. Panse, Eric A. Jensen, Kristopher W. Cummings, Clinton E. Jokerst, Michael Gotway

Research output: Contribution to journalArticle

Abstract

Metastatic disease may affect the thorax in a number of different ways, most commonly in the form of lung nodules, lymph node enlargement, pleural effusion, and osseous lesions. Much less commonly, extrathoracic malignancies may embolize to the lungs. Large vessel tumor emboli may be detected in thoracic imaging studies as pulmonary arterial filling defects or as "beaded"-appearing pulmonary vessels. Occasionally, tumor embolization may affect only the small pulmonary arteries and may induce fibrocellular intimal hyperplasia and produce thrombotic vascular occlusion, resulting in increased pulmonary vascular resistance and elevated pulmonary arterial pressure, potentially precipitating right ventricular failure: this condition is referred to as pulmonary tumor thrombotic microangiopathy. Patients with tumor thrombotic microangiopathy may present with worsening shortness of breath and progressive exercise intolerance, eventually manifesting features of right ventricular failure. The imaging features of tumor thrombotic microangiopathy are generally nonspecific, but thoracic computed tomography may show small nodular opacities with branching configurations resembling infectious bronchiolitis, or mosaic perfusion due to small vessel obstruction producing pulmonary perfusion derangements. Ventilation-perfusion scintigraphy will commonly show small, often nonsegmental, mismatched perfusion defects, and positron emission tomography may show hypermetabolism. The diagnosis of tumor thrombotic microangiopathy may be suspected in patients with known extrathoracic malignancy with persistent, progressive imaging abnormalities and unexplained dyspnea or hypoxemia, particularly when features of pulmonary hypertension are evident, although the diagnosis is rarely established before death.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalClinical Pulmonary Medicine
Volume24
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Thrombotic Microangiopathies
Lung
Neoplasms
Thorax
Perfusion
Dyspnea
Tunica Intima
Bronchiolitis
Perfusion Imaging
Pleural Effusion
Embolism
Pulmonary Hypertension
Vascular Resistance
Positron-Emission Tomography
Pulmonary Artery
Hyperplasia
Blood Vessels
Ventilation
Arterial Pressure
Lymph Nodes

Keywords

  • Cor pulmonale
  • Oligemia
  • Right ventricular failure
  • Thrombotic microangiopathy
  • Tumor embolism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Panse, P. M., Jensen, E. A., Cummings, K. W., Jokerst, C. E., & Gotway, M. (2017). A rare cause of right ventricular failure. Clinical Pulmonary Medicine, 24(1), 33-36. https://doi.org/10.1097/CPM.0000000000000194

A rare cause of right ventricular failure. / Panse, Prasad M.; Jensen, Eric A.; Cummings, Kristopher W.; Jokerst, Clinton E.; Gotway, Michael.

In: Clinical Pulmonary Medicine, Vol. 24, No. 1, 2017, p. 33-36.

Research output: Contribution to journalArticle

Panse, PM, Jensen, EA, Cummings, KW, Jokerst, CE & Gotway, M 2017, 'A rare cause of right ventricular failure', Clinical Pulmonary Medicine, vol. 24, no. 1, pp. 33-36. https://doi.org/10.1097/CPM.0000000000000194
Panse, Prasad M. ; Jensen, Eric A. ; Cummings, Kristopher W. ; Jokerst, Clinton E. ; Gotway, Michael. / A rare cause of right ventricular failure. In: Clinical Pulmonary Medicine. 2017 ; Vol. 24, No. 1. pp. 33-36.
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