A randomized study to improve care for young women with breast cancer at community and academic medical oncology practices in the United States: The Young and Strong study

Ann H. Partridge, Kathryn J Ruddy, William T. Barry, Mary L. Greaney, Jennifer A. Ligibel, Kim M. Sprunck-Harrild, Shoshana M. Rosenberg, Emily L. Baker, J. Russell Hoverman, Karen M. Emmons

Research output: Contribution to journalArticle

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Abstract

Background: The authors conducted a cluster randomized study to determine the effect of an exportable educational intervention for young women with breast cancer (YWI) on improving care. Methods: Sites were randomized 1:1 to the YWI or a contact time control physical activity intervention (PAI) stratified by academic or community site. Up to 15 women aged ≤45 years with newly diagnosed breast cancer were enrolled at each of 14 academic sites and 10 were enrolled at each of 40 community sites. The primary endpoint, attention to fertility, was ascertained by medical record review. Statistical inferences concerning the effect of the intervention used general estimating equations for clustered data. Results: A total of 467 patients across 54 sites were enrolled between July 2012 and December 2013. The median age of the patients at the time of diagnosis was 40 years (range, 22-45 years). Attention to fertility by 3 months was observed in 55% of patients in the YWI and 58% of patients in the PAI (P =.88). Rates were found to be strongly correlated with age (P <.0001), and were highest in patients aged <30 years. Attention to genetics was similar (80% in the YWI and 81% in the PAI), whereas attention to emotional health was higher in patients in the YWI (87% vs 76%; estimated odds ratio, 2.63 [95% confidence interval, 1.20-5.76; P =.016]). Patients rated both interventions as valuable in providing education (64% in the YWI and 63% in the PAI). Conclusions: The current study failed to demonstrate differences in attention to fertility with an intervention to improve care for women with breast cancer, although attention to fertility was found to be higher than expected in both groups and emotional health was improved in the YWI group. Greater attention to young women with breast cancer in general may promote more comprehensive care for this population.

Original languageEnglish (US)
JournalCancer
DOIs
StatePublished - Jan 1 2019

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Medical Oncology
Breast Neoplasms
Fertility
Exercise
Health
Medical Records
Odds Ratio
Confidence Intervals
Education
Population

Keywords

  • breast cancer
  • exercise
  • fertility
  • oncology
  • patient communication
  • psychosocial distress
  • young women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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A randomized study to improve care for young women with breast cancer at community and academic medical oncology practices in the United States : The Young and Strong study. / Partridge, Ann H.; Ruddy, Kathryn J; Barry, William T.; Greaney, Mary L.; Ligibel, Jennifer A.; Sprunck-Harrild, Kim M.; Rosenberg, Shoshana M.; Baker, Emily L.; Hoverman, J. Russell; Emmons, Karen M.

In: Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Partridge, Ann H. ; Ruddy, Kathryn J ; Barry, William T. ; Greaney, Mary L. ; Ligibel, Jennifer A. ; Sprunck-Harrild, Kim M. ; Rosenberg, Shoshana M. ; Baker, Emily L. ; Hoverman, J. Russell ; Emmons, Karen M. / A randomized study to improve care for young women with breast cancer at community and academic medical oncology practices in the United States : The Young and Strong study. In: Cancer. 2019.
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abstract = "Background: The authors conducted a cluster randomized study to determine the effect of an exportable educational intervention for young women with breast cancer (YWI) on improving care. Methods: Sites were randomized 1:1 to the YWI or a contact time control physical activity intervention (PAI) stratified by academic or community site. Up to 15 women aged ≤45 years with newly diagnosed breast cancer were enrolled at each of 14 academic sites and 10 were enrolled at each of 40 community sites. The primary endpoint, attention to fertility, was ascertained by medical record review. Statistical inferences concerning the effect of the intervention used general estimating equations for clustered data. Results: A total of 467 patients across 54 sites were enrolled between July 2012 and December 2013. The median age of the patients at the time of diagnosis was 40 years (range, 22-45 years). Attention to fertility by 3 months was observed in 55{\%} of patients in the YWI and 58{\%} of patients in the PAI (P =.88). Rates were found to be strongly correlated with age (P <.0001), and were highest in patients aged <30 years. Attention to genetics was similar (80{\%} in the YWI and 81{\%} in the PAI), whereas attention to emotional health was higher in patients in the YWI (87{\%} vs 76{\%}; estimated odds ratio, 2.63 [95{\%} confidence interval, 1.20-5.76; P =.016]). Patients rated both interventions as valuable in providing education (64{\%} in the YWI and 63{\%} in the PAI). Conclusions: The current study failed to demonstrate differences in attention to fertility with an intervention to improve care for women with breast cancer, although attention to fertility was found to be higher than expected in both groups and emotional health was improved in the YWI group. Greater attention to young women with breast cancer in general may promote more comprehensive care for this population.",
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AU - Partridge, Ann H.

AU - Ruddy, Kathryn J

AU - Barry, William T.

AU - Greaney, Mary L.

AU - Ligibel, Jennifer A.

AU - Sprunck-Harrild, Kim M.

AU - Rosenberg, Shoshana M.

AU - Baker, Emily L.

AU - Hoverman, J. Russell

AU - Emmons, Karen M.

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N2 - Background: The authors conducted a cluster randomized study to determine the effect of an exportable educational intervention for young women with breast cancer (YWI) on improving care. Methods: Sites were randomized 1:1 to the YWI or a contact time control physical activity intervention (PAI) stratified by academic or community site. Up to 15 women aged ≤45 years with newly diagnosed breast cancer were enrolled at each of 14 academic sites and 10 were enrolled at each of 40 community sites. The primary endpoint, attention to fertility, was ascertained by medical record review. Statistical inferences concerning the effect of the intervention used general estimating equations for clustered data. Results: A total of 467 patients across 54 sites were enrolled between July 2012 and December 2013. The median age of the patients at the time of diagnosis was 40 years (range, 22-45 years). Attention to fertility by 3 months was observed in 55% of patients in the YWI and 58% of patients in the PAI (P =.88). Rates were found to be strongly correlated with age (P <.0001), and were highest in patients aged <30 years. Attention to genetics was similar (80% in the YWI and 81% in the PAI), whereas attention to emotional health was higher in patients in the YWI (87% vs 76%; estimated odds ratio, 2.63 [95% confidence interval, 1.20-5.76; P =.016]). Patients rated both interventions as valuable in providing education (64% in the YWI and 63% in the PAI). Conclusions: The current study failed to demonstrate differences in attention to fertility with an intervention to improve care for women with breast cancer, although attention to fertility was found to be higher than expected in both groups and emotional health was improved in the YWI group. Greater attention to young women with breast cancer in general may promote more comprehensive care for this population.

AB - Background: The authors conducted a cluster randomized study to determine the effect of an exportable educational intervention for young women with breast cancer (YWI) on improving care. Methods: Sites were randomized 1:1 to the YWI or a contact time control physical activity intervention (PAI) stratified by academic or community site. Up to 15 women aged ≤45 years with newly diagnosed breast cancer were enrolled at each of 14 academic sites and 10 were enrolled at each of 40 community sites. The primary endpoint, attention to fertility, was ascertained by medical record review. Statistical inferences concerning the effect of the intervention used general estimating equations for clustered data. Results: A total of 467 patients across 54 sites were enrolled between July 2012 and December 2013. The median age of the patients at the time of diagnosis was 40 years (range, 22-45 years). Attention to fertility by 3 months was observed in 55% of patients in the YWI and 58% of patients in the PAI (P =.88). Rates were found to be strongly correlated with age (P <.0001), and were highest in patients aged <30 years. Attention to genetics was similar (80% in the YWI and 81% in the PAI), whereas attention to emotional health was higher in patients in the YWI (87% vs 76%; estimated odds ratio, 2.63 [95% confidence interval, 1.20-5.76; P =.016]). Patients rated both interventions as valuable in providing education (64% in the YWI and 63% in the PAI). Conclusions: The current study failed to demonstrate differences in attention to fertility with an intervention to improve care for women with breast cancer, although attention to fertility was found to be higher than expected in both groups and emotional health was improved in the YWI group. Greater attention to young women with breast cancer in general may promote more comprehensive care for this population.

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KW - exercise

KW - fertility

KW - oncology

KW - patient communication

KW - psychosocial distress

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