A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury

Mark K. Lyons; Michael D. Partington; Fredric B. Meyer; Gary M. Yarkony; Elliot J. Roth; Moris Senegor; Henry G. Stifel; Margaret Brown; Michael B. Bracken; Mary jo Shepard; William F. Collins; Theodore R. Holford; Wise Young; Joseph Piepmeier; Linda Leo-Summers; David S. Baskin; Howard M. Eisenberg; Eugene Flamm; Lawrence F. Marshall; Joseph Maroon; Jack Wilberger; Phanor L. Perot; Volker K.h. Sonntag; Franklin C. Wagner; H. Richard Winn

doi:10.1056/NEJM199010253231712

A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury

Mark K. Lyons, Michael D. Partington, Fredric B. Meyer, Gary M. Yarkony, Elliot J. Roth, Moris Senegor, Henry G. Stifel, Margaret Brown, Michael B. Bracken, Mary jo Shepard, William F. Collins, Theodore R. Holford, Wise Young, Joseph Piepmeier, Linda Leo-Summers, David S. Baskin, Howard M. Eisenberg, Eugene Flamm, Lawrence F. Marshall, Joseph MaroonJack Wilberger, Phanor L. Perot, Volker K.h. Sonntag, Franklin C. Wagner, H. Richard Winn

Neurosurgery

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

To the Editor: After reading the recent article by Bracken et al. (May 17 issue),¹ we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.² Bracken et al.³ reported previously that a complete sensory examination (including tests of proprioception) was.

Original language	English (US)
Pages (from-to)	1207-1209
Number of pages	3
Journal	New England Journal of Medicine
Volume	323
Issue number	17
DOIs	https://doi.org/10.1056/NEJM199010253231712
State	Published - Oct 25 1990

ASJC Scopus subject areas

General Medicine

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Lyons, M. K., Partington, M. D., Meyer, F. B., Yarkony, G. M., Roth, E. J., Senegor, M., Stifel, H. G., Brown, M., Bracken, M. B., Shepard, M. J., Collins, W. F., Holford, T. R., Young, W., Piepmeier, J., Leo-Summers, L., Baskin, D. S., Eisenberg, H. M., Flamm, E., Marshall, L. F., ... Winn, H. R. (1990). A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. New England Journal of Medicine, 323(17), 1207-1209. https://doi.org/10.1056/NEJM199010253231712

Lyons, MK, Partington, MD, Meyer, FB, Yarkony, GM, Roth, EJ, Senegor, M, Stifel, HG, Brown, M, Bracken, MB, Shepard, MJ, Collins, WF, Holford, TR, Young, W, Piepmeier, J, Leo-Summers, L, Baskin, DS, Eisenberg, HM, Flamm, E, Marshall, LF, Maroon, J, Wilberger, J, Perot, PL, Sonntag, VKH, Wagner, FC & Winn, HR 1990, 'A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury', New England Journal of Medicine, vol. 323, no. 17, pp. 1207-1209. https://doi.org/10.1056/NEJM199010253231712

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title = "A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury",

abstract = "To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.",

author = "Lyons, {Mark K.} and Partington, {Michael D.} and Meyer, {Fredric B.} and Yarkony, {Gary M.} and Roth, {Elliot J.} and Moris Senegor and Stifel, {Henry G.} and Margaret Brown and Bracken, {Michael B.} and Shepard, {Mary jo} and Collins, {William F.} and Holford, {Theodore R.} and Wise Young and Joseph Piepmeier and Linda Leo-Summers and Baskin, {David S.} and Eisenberg, {Howard M.} and Eugene Flamm and Marshall, {Lawrence F.} and Joseph Maroon and Jack Wilberger and Perot, {Phanor L.} and Sonntag, {Volker K.h.} and Wagner, {Franklin C.} and Winn, {H. Richard}",

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doi = "10.1056/NEJM199010253231712",

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AU - Lyons, Mark K.

AU - Partington, Michael D.

AU - Meyer, Fredric B.

AU - Yarkony, Gary M.

AU - Roth, Elliot J.

AU - Senegor, Moris

AU - Stifel, Henry G.

AU - Brown, Margaret

AU - Bracken, Michael B.

AU - Shepard, Mary jo

AU - Collins, William F.

AU - Holford, Theodore R.

AU - Young, Wise

AU - Piepmeier, Joseph

AU - Leo-Summers, Linda

AU - Baskin, David S.

AU - Eisenberg, Howard M.

AU - Flamm, Eugene

AU - Marshall, Lawrence F.

AU - Maroon, Joseph

AU - Wilberger, Jack

AU - Perot, Phanor L.

AU - Sonntag, Volker K.h.

AU - Wagner, Franklin C.

AU - Winn, H. Richard

PY - 1990/10/25

Y1 - 1990/10/25

N2 - To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.

AB - To the Editor: After reading the recent article by Bracken et al. (May 17 issue),1 we have several questions regarding data not discussed that would facilitate our analysis of this very important work. First, we understand from the description of the neurologic examination that proprioceptive function was not recorded and that in patients with a “complete” injury, proprioception may have been intact. A recent study suggests that the presence or absence of proprioception is strongly predictive of neurologic outcome in patients with acute spinal-cord injury.2 Bracken et al.3 reported previously that a complete sensory examination (including tests of proprioception) was.

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A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury

Abstract

ASJC Scopus subject areas

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