A randomized clinical trial of St. John's wort for smoking cessation

Amit Sood, Jon Owen Ebbert, Kavita Prasad, Ivana T Croghan, Brent A Bauer, Darrell R. Schroeder

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Introduction: St. John's wort (SJW) is a widely used herbal supplement. The predominant mechanism(s) accounting for the activity of SJW in vivo are, however, unclear. The purpose of this study was to investigate the efficacy of SJW for smoking cessation. Methods: We conducted a randomized, blinded, placebo-controlled, three-arm, dose-ranging clinical trial. A total of 118 subjects were randomly allocated to receive SJW 300mg, 600mg, or a matching placebo tablet 3 times a day combined with a behavioral intervention for 12 weeks. Self-reported smoking abstinence was biochemically confirmed with expired air carbon monoxide. Results: Mean age of the study participants was 37.6±12.4 years; they smoked an average of 20.0±6.6 cigarettes per day for 20±12.1 years. The study dropout rate was high (43%). By intention-to-treat analysis, no significant differences were observed in abstinence rates at 12 and 24 weeks between SJW dose groups and placebo. SJW did not attenuate withdrawal symptoms among abstinent subjects. Abstinence rates did not differ by study group among subjects who took at least 75% of their study medication. No significant side-effects were noted with SJW. Conclusions: In this randomized trial, SJW did not increase smoking abstinence rates. Our data, in combination with data from other studies, suggest that SJW has little role in the treatment of tobacco dependence.

Original languageEnglish (US)
Pages (from-to)761-767
Number of pages7
JournalJournal of Alternative and Complementary Medicine
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2010

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Hypericum
Smoking Cessation
Randomized Controlled Trials
Placebos
Smoking
Tobacco Use Disorder
Substance Withdrawal Syndrome
Intention to Treat Analysis
Carbon Monoxide
Tobacco Products
Tablets
Air
Clinical Trials

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Medicine(all)

Cite this

A randomized clinical trial of St. John's wort for smoking cessation. / Sood, Amit; Ebbert, Jon Owen; Prasad, Kavita; Croghan, Ivana T; Bauer, Brent A; Schroeder, Darrell R.

In: Journal of Alternative and Complementary Medicine, Vol. 16, No. 7, 01.07.2010, p. 761-767.

Research output: Contribution to journalArticle

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