A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

Howard E. Gendelman, Gholam H. Pezeshkpour, Norman J. Pressman, Jerry S. Wolinsky, Richard H. Quarles, Michael J. Dobersen, Bruce D. Trapp, Cheryl A. Kitt, Allen Aksamit, Richard T. Johnson

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45 Scopus citations

Abstract

The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalAnnals of neurology
Volume18
Issue number3
DOIs
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Gendelman, H. E., Pezeshkpour, G. H., Pressman, N. J., Wolinsky, J. S., Quarles, R. H., Dobersen, M. J., Trapp, B. D., Kitt, C. A., Aksamit, A., & Johnson, R. T. (1985). A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease. Annals of neurology, 18(3), 324-328. https://doi.org/10.1002/ana.410180309