A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

Howard E. Gendelman; Gholam H. Pezeshkpour; Norman J. Pressman; Jerry S. Wolinsky; Richard H. Quarles; Michael J. Dobersen; Bruce D. Trapp; Cheryl A. Kitt; Allen Aksamit; Richard T. Johnson

doi:10.1002/ana.410180309

A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

Howard E. Gendelman, Gholam H. Pezeshkpour, Norman J. Pressman, Jerry S. Wolinsky, Richard H. Quarles, Michael J. Dobersen, Bruce D. Trapp, Cheryl A. Kitt, Allen Aksamit, Richard T. Johnson

Neurology

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45 Scopus citations

Abstract

The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.

Original language	English (US)
Pages (from-to)	324-328
Number of pages	5
Journal	Annals of neurology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1002/ana.410180309
State	Published - Sep 1985

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease",

abstract = "The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.",

author = "Gendelman, {Howard E.} and Pezeshkpour, {Gholam H.} and Pressman, {Norman J.} and Wolinsky, {Jerry S.} and Quarles, {Richard H.} and Dobersen, {Michael J.} and Trapp, {Bruce D.} and Kitt, {Cheryl A.} and Allen Aksamit and Johnson, {Richard T.}",

year = "1985",

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T1 - A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

AU - Gendelman, Howard E.

AU - Pezeshkpour, Gholam H.

AU - Pressman, Norman J.

AU - Wolinsky, Jerry S.

AU - Quarles, Richard H.

AU - Dobersen, Michael J.

AU - Trapp, Bruce D.

AU - Kitt, Cheryl A.

AU - Aksamit, Allen

AU - Johnson, Richard T.

PY - 1985/9

Y1 - 1985/9

N2 - The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.

AB - The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.

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A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

Abstract

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