A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types

Kai Li Liaw, Allan Hildesheim, Robert D. Burk, Patti Gravitt, Sholom Wacholder, M. Michele Manos, David R. Scott, Mark E. Sherman, Robert J. Kurman, Andrew G. Glass, Steven M. Anderson, Mark Schiffman

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Human papillomavirus (HPV)-16 causes about half the cases of cervical cancer worldwide and is the focus of HPV vaccine development efforts. Systematic data are lacking as to whether the prevention of HPV-16 could affect the equilibrium of infection with other HPV types and thus alter the predicted impact of vaccination on the occurrence of cervical neoplasia. Therefore, the associations of HPV-16 detection with subsequent acquisition of other HPV types and with the persistence of concomitantly detected HPV types were examined prospectively among 1124 initially cytologically normal women. Preexisting HPV-16 was generally associated with an increased risk for subsequent acquisition of other types. HPV-16 did not affect the persistence of concomitant infections, regardless of type. These findings suggest that the prevention or removal of HPV-16 is not likely to promote the risk of infection with other types, a theoretical concern with current vaccination efforts.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Human papillomavirus 16
DNA-Directed DNA Polymerase
Prospective Studies
Polymerase Chain Reaction
Vaccination
Infection
Papillomavirus Vaccines
Uterine Cervical Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types. / Liaw, Kai Li; Hildesheim, Allan; Burk, Robert D.; Gravitt, Patti; Wacholder, Sholom; Manos, M. Michele; Scott, David R.; Sherman, Mark E.; Kurman, Robert J.; Glass, Andrew G.; Anderson, Steven M.; Schiffman, Mark.

In: Journal of Infectious Diseases, Vol. 183, No. 1, 2001, p. 8-15.

Research output: Contribution to journalArticle

Liaw, KL, Hildesheim, A, Burk, RD, Gravitt, P, Wacholder, S, Manos, MM, Scott, DR, Sherman, ME, Kurman, RJ, Glass, AG, Anderson, SM & Schiffman, M 2001, 'A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types', Journal of Infectious Diseases, vol. 183, no. 1, pp. 8-15. https://doi.org/10.1086/317638
Liaw, Kai Li ; Hildesheim, Allan ; Burk, Robert D. ; Gravitt, Patti ; Wacholder, Sholom ; Manos, M. Michele ; Scott, David R. ; Sherman, Mark E. ; Kurman, Robert J. ; Glass, Andrew G. ; Anderson, Steven M. ; Schiffman, Mark. / A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 1. pp. 8-15.
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