A Prospective, Randomized Platelet-Function Study of Heparinized Oxygenators and Cardiotomy Suction

Gregory A. Nuttall, William C. Oliver, David N. Fass, Whyte G. Owen, Devin Dinenno, Mark H. Ereth, Brent A. Williams, Joseph A. Dearani, Hartzell V. Schaff

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: The purpose of this study was to determine if substitution of a heparin-coated oxygenator and salvaged autologous blood for cardiotomy suction would improve platelet function. Design: A prospective, randomized trial. Setting: A large academic medical center. Participants: Sixty adult patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass (CPB). Interventions: Patients were randomized into 1 of 4 groups in a 2 × 2 factorial design by oxygenator (heparinized v nonheparinized) and blood salvage during CPB (cardiotomy suction v salvaged autologous blood). Measurements and Main Results: Primary outcome measures were platelet function, glass-bead retention, platelet dense-body adenosine triphosphate secretion, platelet-rich plasma (PRP) aggregometry, Plateletworks platelet-function analyzer (Helena Laboratories Corp, Allen Park, MI), and platelet count. Secondary outcome measures were chest-tube drainage and allogeneic blood transfusion requirements. All platelet-function tests except thrombin-receptor activator peptide-induced PRP aggregometry showed a reduction in platelet function during and immediately after CPB (all p < 0.05). The only statistically significant difference in platelet-function tests between the groups was the glass-bead assay at 5 minutes before discontinuation of CPB (p < 0.05). This difference resolved 10 minutes after protamine administration. There were no differences between the groups in the amount of blood transfused, chest-tube drainage, and routine laboratory test results. Conclusions: The authors concluded that the effects of these changes to the CPB circuit were small and inconsequential in this cohort of patients.

Original languageEnglish (US)
Pages (from-to)554-561
Number of pages8
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2006

Keywords

  • cardiac surgery
  • cardiopulmonary bypass
  • heparin
  • oxygenators
  • platelet function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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    Nuttall, G. A., Oliver, W. C., Fass, D. N., Owen, W. G., Dinenno, D., Ereth, M. H., Williams, B. A., Dearani, J. A., & Schaff, H. V. (2006). A Prospective, Randomized Platelet-Function Study of Heparinized Oxygenators and Cardiotomy Suction. Journal of Cardiothoracic and Vascular Anesthesia, 20(4), 554-561. https://doi.org/10.1053/j.jvca.2006.01.021