A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery

William C. Oliver, Gregory A. Nuttall, Terri Murari, Lori K. Bauer, Kelly H. Johnsrud, Kirsten J. Hall Long, Thomas A. Orszulak, Hartzell V Schaff, Andrew C. Hanson, Darrell R. Schroeder, Mark H. Ereth, Martin D. Abel

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Abstract

Objective The aim of this study was to evaluate cardiac risk as a consideration for selecting postoperative sedation and analgesia regimens used for cardiac surgical patients requiring cardiopulmonary bypass and early extubation. Design An observer-blind, randomized, controlled trial. Setting A tertiary referral medical center involving an intensive care unit. Participants One hundred forty-five adults requiring elective cardiac surgery. Interventions Patients were stratified preoperatively as low, moderate, or high cardiac risk based on established criteria and then assigned to 1 of 3 postoperative regimens: propofol infusion beginning at 25 μg/kg/min and morphine boluses (P), fentanyl infusion beginning at 2 μg/kg/h and midazolam boluses (F), or propofol and fentanyl infusions beginning at 25 μg/kg/min and 0.5 μg/kg/h (PF), respectively. Measurements and Main Results Postoperative regimen P was associated with a significantly reduced time to extubation (median value, 264 minutes; p = 0.05) compared with F (295 minutes) but not PF (278 minutes) in patients characterized as low cardiac risk. The time to extubation did not differ among regimens in patients of moderate/high cardiac risk. Conclusion Patients with low cardiac risk undergoing cardiac surgery had statistically significantly shorter times to extubation with propofol infusion and intermittent morphine than a fentanyl infusion and intermittent midazolam. These differences were not sustained in patients considered at higher cardiac risk. The time to extubation after cardiac surgery may further improve if postoperative sedation and analgesia are not administered uniformly to all patients but selected based on individual characteristics.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume25
Issue number1
DOIs
StatePublished - Feb 2011

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Analgesia
Thoracic Surgery
Fentanyl
Propofol
Midazolam
Morphine
Cardiopulmonary Bypass
Tertiary Care Centers
Intensive Care Units
Randomized Controlled Trials

Keywords

  • analgesia
  • cardiac surgery
  • fentanyl
  • intensive care unit
  • mechanical ventilation
  • midazolam
  • propofol
  • sedation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

Cite this

Oliver, W. C., Nuttall, G. A., Murari, T., Bauer, L. K., Johnsrud, K. H., Hall Long, K. J., ... Abel, M. D. (2011). A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia, 25(1), 110-119. https://doi.org/10.1053/j.jvca.2010.07.008

A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery. / Oliver, William C.; Nuttall, Gregory A.; Murari, Terri; Bauer, Lori K.; Johnsrud, Kelly H.; Hall Long, Kirsten J.; Orszulak, Thomas A.; Schaff, Hartzell V; Hanson, Andrew C.; Schroeder, Darrell R.; Ereth, Mark H.; Abel, Martin D.

In: Journal of Cardiothoracic and Vascular Anesthesia, Vol. 25, No. 1, 02.2011, p. 110-119.

Research output: Contribution to journalArticle

Oliver, WC, Nuttall, GA, Murari, T, Bauer, LK, Johnsrud, KH, Hall Long, KJ, Orszulak, TA, Schaff, HV, Hanson, AC, Schroeder, DR, Ereth, MH & Abel, MD 2011, 'A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery', Journal of Cardiothoracic and Vascular Anesthesia, vol. 25, no. 1, pp. 110-119. https://doi.org/10.1053/j.jvca.2010.07.008
Oliver, William C. ; Nuttall, Gregory A. ; Murari, Terri ; Bauer, Lori K. ; Johnsrud, Kelly H. ; Hall Long, Kirsten J. ; Orszulak, Thomas A. ; Schaff, Hartzell V ; Hanson, Andrew C. ; Schroeder, Darrell R. ; Ereth, Mark H. ; Abel, Martin D. / A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery. In: Journal of Cardiothoracic and Vascular Anesthesia. 2011 ; Vol. 25, No. 1. pp. 110-119.
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abstract = "Objective The aim of this study was to evaluate cardiac risk as a consideration for selecting postoperative sedation and analgesia regimens used for cardiac surgical patients requiring cardiopulmonary bypass and early extubation. Design An observer-blind, randomized, controlled trial. Setting A tertiary referral medical center involving an intensive care unit. Participants One hundred forty-five adults requiring elective cardiac surgery. Interventions Patients were stratified preoperatively as low, moderate, or high cardiac risk based on established criteria and then assigned to 1 of 3 postoperative regimens: propofol infusion beginning at 25 μg/kg/min and morphine boluses (P), fentanyl infusion beginning at 2 μg/kg/h and midazolam boluses (F), or propofol and fentanyl infusions beginning at 25 μg/kg/min and 0.5 μg/kg/h (PF), respectively. Measurements and Main Results Postoperative regimen P was associated with a significantly reduced time to extubation (median value, 264 minutes; p = 0.05) compared with F (295 minutes) but not PF (278 minutes) in patients characterized as low cardiac risk. The time to extubation did not differ among regimens in patients of moderate/high cardiac risk. Conclusion Patients with low cardiac risk undergoing cardiac surgery had statistically significantly shorter times to extubation with propofol infusion and intermittent morphine than a fentanyl infusion and intermittent midazolam. These differences were not sustained in patients considered at higher cardiac risk. The time to extubation after cardiac surgery may further improve if postoperative sedation and analgesia are not administered uniformly to all patients but selected based on individual characteristics.",
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AU - Johnsrud, Kelly H.

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AU - Orszulak, Thomas A.

AU - Schaff, Hartzell V

AU - Hanson, Andrew C.

AU - Schroeder, Darrell R.

AU - Ereth, Mark H.

AU - Abel, Martin D.

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KW - intensive care unit

KW - mechanical ventilation

KW - midazolam

KW - propofol

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