A proposal for standardized grading of chronic changes in native kidney biopsy specimens

Sanjeev M Sethi, Vivette D. D'Agati, Cynthia C. Nast, Agnes B. Fogo, An S. De Vriese, Glen S. Markowitz, Richard J. Glassock, Fernando Custodio Fervenza, Surya V. Seshan, Andrew D Rule, Lorraine C. Racusen, Jai Radhakrishnan, Christopher G. Winearls, Gerald B. Appel, Ingeborg M. Bajema, Anthony Chang, Robert B. Colvin, H. Terence Cook, Sundaram Hariharan, Loren P. Herrera HernandezNeeraja Kambham, Michael Mengel, Karl A Nath, Helmut G. Rennke, Pierre Ronco, Brad H. Rovin, Mark Haas

Research output: Contribution to journalArticle

35 Scopus citations


Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.

Original languageEnglish (US)
Pages (from-to)787-789
Number of pages3
JournalKidney International
Issue number4
StatePublished - Apr 1 2017



  • arteriosclerosis
  • glomerulosclerosis
  • interstitial fibrosis
  • native kidney biopsy
  • tubular atrophy

ASJC Scopus subject areas

  • Medicine(all)
  • Nephrology

Cite this

Sethi, S. M., D'Agati, V. D., Nast, C. C., Fogo, A. B., De Vriese, A. S., Markowitz, G. S., Glassock, R. J., Fervenza, F. C., Seshan, S. V., Rule, A. D., Racusen, L. C., Radhakrishnan, J., Winearls, C. G., Appel, G. B., Bajema, I. M., Chang, A., Colvin, R. B., Cook, H. T., Hariharan, S., ... Haas, M. (2017). A proposal for standardized grading of chronic changes in native kidney biopsy specimens. Kidney International, 91(4), 787-789. https://doi.org/10.1016/j.kint.2017.01.002