A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers

Erik G. Jönsson, Nadine Norton, J. Petter Gustavsson, Lars Oreland, Michael J. Owen, Göran C. Sedvall

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated possible relationships between a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene and CSF concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n=88). Among women (n=37), those carrying at least one copy of the alleles associated with more efficient transcription displayed higher concentrations of HVA (p=0.01) and 5-HIAA (p=0.01). In men (n=51), however, there was a tendency in the opposite direction. The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. The results should be interpreted with caution until replicated because of the limited sample size. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalJournal of Psychiatric Research
Volume34
Issue number3
DOIs
StatePublished - May 1 2000

Keywords

  • 5-HIAA
  • Cerebrospinal fluid
  • MHPG)
  • Monoamine metabolites (HVA
  • Monoamine oxidase A gene

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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