A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease

Paola Ricci, Terry M Therneau, Michael Malinchoc, Joanne T. Benson, Jan L. Petz, Goran B. Klintmalm, Jeffrey S. Crippin, Russell H. Wiesner, Jeffrey L. Steers, Jorge Rakela, Thomas E. Starzl, E. Rolland Dickson

Research output: Contribution to journalArticle

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Abstract

We studied the outcome of 436 patients with primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) who underwent orthotopic liver transplant (OLT) at three major liver transplant centers. Univariate predictors of outcome included age, Karnofsky score, Child's class, Mayo risk score, United Network for Organ Sharing (UNOS) status, nutritional status, serum albumin, serum bilirubin, international normalized ratio, and the presence of ascites, encephalopathy, renal failure (serum creatinine > 2 mg/dL), and edema refractory to diuretics. Using these predictors, we developed a four variable mathematical prognostic model to help the liver transplant physician predict the following: 1) the amount of intraoperative blood loss; 2) the number of days in the intensive care unit (ICU); and 3) severe complications after surgery. The model uses age, renal failure, Child's class, and United Network for Organ Sharing status. This study is the first to model the outcome of liver transplant in patients with a specific etiology of chronic liver disease (PBC or PSC). The model may be used to help select patients for OLT and to plan the timing of their transplantation.

Original languageEnglish (US)
Pages (from-to)672-677
Number of pages6
JournalHepatology
Volume25
Issue number3
DOIs
StatePublished - 1997

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Liver Transplantation
Liver Diseases
Transplants
Liver
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Renal Insufficiency
International Normalized Ratio
Brain Diseases
Nutritional Status
Serum
Bilirubin
Diuretics
Ascites
Serum Albumin
Intensive Care Units
Edema
Creatinine
Chronic Disease
Theoretical Models

ASJC Scopus subject areas

  • Hepatology

Cite this

Ricci, P., Therneau, T. M., Malinchoc, M., Benson, J. T., Petz, J. L., Klintmalm, G. B., ... Rolland Dickson, E. (1997). A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease. Hepatology, 25(3), 672-677. https://doi.org/10.1002/hep.510250330

A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease. / Ricci, Paola; Therneau, Terry M; Malinchoc, Michael; Benson, Joanne T.; Petz, Jan L.; Klintmalm, Goran B.; Crippin, Jeffrey S.; Wiesner, Russell H.; Steers, Jeffrey L.; Rakela, Jorge; Starzl, Thomas E.; Rolland Dickson, E.

In: Hepatology, Vol. 25, No. 3, 1997, p. 672-677.

Research output: Contribution to journalArticle

Ricci, P, Therneau, TM, Malinchoc, M, Benson, JT, Petz, JL, Klintmalm, GB, Crippin, JS, Wiesner, RH, Steers, JL, Rakela, J, Starzl, TE & Rolland Dickson, E 1997, 'A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease', Hepatology, vol. 25, no. 3, pp. 672-677. https://doi.org/10.1002/hep.510250330
Ricci, Paola ; Therneau, Terry M ; Malinchoc, Michael ; Benson, Joanne T. ; Petz, Jan L. ; Klintmalm, Goran B. ; Crippin, Jeffrey S. ; Wiesner, Russell H. ; Steers, Jeffrey L. ; Rakela, Jorge ; Starzl, Thomas E. ; Rolland Dickson, E. / A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease. In: Hepatology. 1997 ; Vol. 25, No. 3. pp. 672-677.
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