Laparoendoscopic single site surgery (LESS) can provide potential patient benefits beyond conventional laparoscopy (CL). However, LESS further exacerbates current ergonomic disadvantages of CL. LESS practices to compensate for the constraints include intracorporeal crossing of instruments (UL) for improved manipulation of instrumentation and extracorporeal crossing of hands (PL) for illusion mitigation. Preliminary results from this study involving 12 medical students (7 males) performing a simulated surgical task found statistical difference between CL, PL, and UL for physical demand (P<0.001), task complexity (P=0.002) and performance times (P<0.001) with no difference for mental demand (P=0.106). These initial findings show that the PL technique cannot currently compensate for the limitations of LESS to make UL more similar to CL. Further research is needed to determine if PL or another LESS compensatory practice can allow surgeons to more effectively perform procedures with a single port and therefore ensure patients reap its benefits.